Smoking Clinical Trial
Official title:
Behavioral Impact of Prefrontal Anodal Transcranial Direct Current Stimulation on Smokers
The aim of this study is to determine whether a powerful technique of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), could reduce cigarette smoking and constitute a treatment of tobacco addiction.
Tobacco is estimated to cause more than 5 millions yearly deaths in the developed world.
Although most smokers would like to quit, relapse rates remain high. It seems that this
relapse is linked with the process of craving, which is a powerful desire to smoke elicited
by smoking deprivation or exposure to situations or cues that are associated with smoking.
Neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC), and
especially the right part, is critically involved in processing the craving of smoking.
Increasing the activity of the DLPFC by noninvasive brain stimulation has been demonstrated
to be effective in decreasing craving symptoms in cigarette smokers.
The aim of this study is to determine whether a powerful technique of noninvasive brain
stimulation, transcranial direct current stimulation (tDCS), could reduce cigarette smoking.
tDCS is a painless and safe brain stimulation method capable of modulating cortical
excitability. The nature of these modulations depends on stimulation polarity: anodal tDCS is
thought to cause neuronal depolarisation and thus enhancing cortical excitability whereas
cathodal stimulation is proposed to reduce excitability. The investigators hypothesize that
anodal tDCS applied repetitively to the right DLPFC could constitute a treatment of tobacco
addiction. Therefore, the investigators will conduct a sham-tDCS-controlled, randomized,
double-blind study.
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