Smoking Clinical Trial
Official title:
Evaluation of the Lungs of Normal Individuals With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing and Bronchial Wall Biopsy
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters. These will provide important information when applied to individuals with various pulmonary diseases, and will help in understanding of the etiology and pathogenesis of various lung diseases.
Study procedures will be performed at the Weill Cornell Medical College-New York
Presbyterian Hospital and/or Weill Greenburg York Avenue Building. Study procedures done
elsewhere that are within the protocol timeframe will be accepted if seen fit by the
investigators so that they are not repeated unnecessarily. Study individuals who undergo
bronchoscopy with intravenous administration of sedatives and analgesia may be required to
stay overnight. Bronchoscopy is normally an ambulatory procedure. The subject is observed
after the bronchoscopy, including vital signs and level of consciousness, until they are
back to baseline. An overnight stay would only be required if the individual was not, in the
judgment of the attending physician, safe to be discharged as is standard practice. Follow
up of all participants are carried out by telephone within 1 wk following the procedure.
Rockefeller University has been added as a second site.
Individuals undergoing bronchoscopy without intravenous administration of sedatives and
analgesia are not required to stay overnight due to the lack of administration of
CNS-altering drugs and the limited sampling involved (tracheal brushes only).
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Observational Model: Case-Only, Time Perspective: Prospective
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