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Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

Smoking Clinical Trial

Official title:
Naltrexone & Bupropion to Stop Smoking With Less Weight Gain

Clinical Trial Summary

This study will test a combination of the drugs naltrexone and bupropion with weight-concerned smokers to investigate whether or not this combination of drugs improves smoking cessation quit rates and minimizes post quit weight gain.

Clinical Trial Description

This is an open label smoking cessation clinical trial of 25 mg naltrexone with 300 mg bupropion sustained-release (SR) in six male and fourteen female participants. This pilot study is being conducted to determine: - effect size estimates for smoking cessation and post-cessation weight gain, which will be used to compute the sample size needed for a large-scale clinical trial; and - compliance with a combination of 25 mg naltrexone and 300 mg bupropion SR. In addition to examining the sample in this study, the investigators plan to compare this sample to a sample of matched controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00129246
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date December 2004
Completion date December 2005
View Details
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