Clinical Trials Logo

Clinical Trial Summary

Periodontitis is considered an inflammatory disease that results in the disruption of oral hemeostasis and is associated with the presence of dental plaque influenced by genetic and environmental factors. It is well-establised that smokers have an increased severity of periodontal disease,a higher prevalance of tooth loss and total edentulism.


Clinical Trial Description

Antimicrobial peptides (AMPs) are soluble molecules participating in the innate immunity of mucosal surfaces against pathogens. Dysregulated expression of AMPs has been considered a possible causal mechanistic link in the microbial dysbiosis associated with periodontal disease and some risk factors, including tobacco smoking, diabetes mellitus, and obesity.Antimicrobial peptides as a part of innate immunity are important molecules that provide a balance between disease and health. Moreover, they are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the gingival epithelium and in the transition to acquired immunity. Cathelicidins, in particular - which play an important role in regulating the immunological response of oral tissues, are a group of peptides released from neutrophil granules and they are present only in humans in the form of LL-37. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04861493
Study type Observational [Patient Registry]
Source Cairo University
Contact
Status Completed
Phase
Start date February 23, 2021
Completion date April 15, 2021

See also
  Status Clinical Trial Phase
Recruiting NCT04133064 - Pivot Breath Sensor Study N/A
Not yet recruiting NCT04572126 - Feasibility and Efficacy of a Brief Mindfulness-Based Intervention SMOKING INTERVENTION VIA THE INTERNET N/A
Not yet recruiting NCT04783857 - Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children Phase 4
Not yet recruiting NCT04620915 - Construal Level as a Novel Pathway for Affect Regulation and Cancer Control N/A
Recruiting NCT03612804 - Promoting Smoking Cessation in Lung Cancer Screening Through Proactive Treatment N/A
Recruiting NCT04857515 - Clinical Learning Study for a Mobile Smoking Cessation Program
Recruiting NCT04808609 - Smoking Cessation Pilot for People Living With HIV (PLWH) N/A
Recruiting NCT03083353 - Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation Early Phase 1
Recruiting NCT04749017 - The Potential Effect of Neuravena on Wellness/Wellbeing During Smoking Reduction/Cessation Experience N/A
Enrolling by invitation NCT04787978 - Creating Healthier Communities Through Meaningful Partnerships: A Model From the National African American Male Wellness Initiative - OSU Partnership N/A
Recruiting NCT04271371 - Preventing Relapse to Smoking Among Prisoners After Release