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Staccato Loxapine PK in Smokers and Nonsmokers

Smoking, Cigarette Clinical Trial

Official title:
Pharmacokinetics of Staccato® Loxapine for Inhalation in Smokers Compared to Nonsmokers

Clinical Trial Summary

The objective of this trial was to assess the pharmacokinetics of a single dose of 10 mg Staccato Loxapine administered to smokers compared to nonsmokers.

Clinical Trial Description

Pharmacokinetics and sedation pharmacodynamics were studied using a visual analog scale were studied in male and female adult subjects (nonsmokers and smokers) following a single dose of 10 mg of inhaled loxapine. Blood samples were drawn at predose, 30 seconds, 1, 2, 3, 10, 30, and 60 minutes, and 2, 6, 12, and 24 hours after dosing. Loxapine and 8-OH-loxapine were analyzed using reverse-phase liquid chromatography coupled with a tandem mass spectrometer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00873769
Study type Interventional
Source Alexza Pharmaceuticals, Inc.
Contact
Status Completed
Phase Phase 1
Start date April 2009
Completion date June 2009
View Details
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