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Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes — BuZonE  

Smoking Cessation Clinical Trial

Official title:
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes

Clinical Trial Summary

This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette. There will be a data collection period of at least five days to obtain baseline data on use of combustible cigarettes. Participants enrolled in the study will receive a G6 e-cigarette at V2 for ad libitum use. After the first week of e-cigarette use, (at V3) participants will be given zonisamide (100 mg/daily) and will begin extended-release bupropion dosing (150 mg each morning days 1-3, then 300 mg/daily) in addition to continued use of the G6. At each visit, participants will receive enough zonisamide, bupropion, and Halo G6 cartomizers to last until their next study visit. Halo G6 and combination zonisamide and bupropion use will continue until the participant returns for the End-of-Study visit (V7).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04388319
Study type Interventional
Source Rose Research Center, LLC
Contact
Status Completed
Phase Phase 3
Start date May 27, 2020
Completion date September 15, 2021
View Details
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