Smoking Cessation Clinical Trial
— COPEOfficial title:
Smoking Cessation and Brain Activation: How Practice Changes the Brain
Verified date | March 2021 |
Source | University of Kansas Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this research study is to help determine whether practicing resisting the urge to smoke changes brain function or behavior among smokers.
Status | Terminated |
Enrollment | 79 |
Est. completion date | March 26, 2020 |
Est. primary completion date | March 26, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Smoke > 10 cigarettes per day for the last 6 months - Smokes first cigarette within 60 minutes after waking - Vision should be normal or corrected-to-normal (to ensure that they can accurately see the images on the screen and select the appropriate response) - Willing to complete all appointments and change smoking behaviors for 2 weeks - No quit attempts or attempts to cut back in the last 30 days - No plans to quit in the next 30 days - High school graduate or General Eduction Diploma (GED) Exclusion Criteria: - Serious medical illness unsuitable for the magnetic resonance imaging (MRI) scanner based on best clinical judgment - Any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder), or attention-deficit disorder/attention-deficit hyperactivity disorder - Currently taking anti-seizure medication - History of concussion - Body mass index (BMI) over 50 - Left-handedness - History of alcohol or other substance dependence or current abuse; - Risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc) - Pregnancy |
Country | Name | City | State |
---|---|---|---|
United States | Hoglund Brain Imaging Center, University of Kansas Medical Center | Kansas City | Kansas |
Lead Sponsor | Collaborator |
---|---|
University of Kansas Medical Center | American Cancer Society, Inc. |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Increase in percent blood oxygenation level dependent (BOLD) signal change in cognitive control network in response to smoking versus nonsmoking cues | Change measured via functional magnetic resonance imaging (fMRI) | Baseline (Day 7) to End of Study (Day 22) | |
Secondary | Decrease in percent (BOLD) signal change in reward network in response to smoking versus nonsmoking cues | Change measured via functional magnetic resonance imaging (fMRI) | Baseline (Day 7) to End of Study (Day 22) |
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