Smoking Cessation Clinical Trial
— rTMS TABACOfficial title:
Evaluation of the Efficacy of Low-frequency rTMS on Craving in Smoking Dependence: Single-centre Randomized, Controlled Blinded Pilot Study
NCT number | NCT02812810 |
Other study ID # | TROJAK DRCI 2010 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | June 20, 2016 |
Last updated | June 22, 2016 |
Start date | September 2011 |
The fight against smoking is a public health priority. Without help, fewer than 5% of des
smokers are abstinent at 12 months after smoking cessation.
Despite well-managed attempts at smoking cessation with nicotine substitutes, the rate of
success at 12 months in patients dependent on nicotine is only 18%. Moreover, other
therapeutic strategies (acupuncture, hypnosis…) have not proved to be effective.
The investigators propose a new therapeutic strategy for smoking cessation, which is based
on associating nicotine substitutes (to reduce physical symptoms of weaning from nicotine)
with rTMS at 1 Hz to the right DorsoLateral PreFrontal Cortex (DLPFC) for 2 weeks (to
diminish craving for tobacco). The principal objective is to improve the success rate for
smoking cessation attempts in patients who are highly dependent on nicotine, and who have
failed using usual smoking cessation strategies.
Status | Completed |
Enrollment | 39 |
Est. completion date | |
Est. primary completion date | February 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Adult 18-65 years old - Wishing to stop smoking - Highly dependent on nicotine (score = 7 on the Fagerström self-questionnaire) - History of at least 2 failed attempts to stop smoking despite recommended treatments (nicotine, vareniciline, bupropion) Exclusion Criteria: - Abstinence in the 3 previous months - Absence of effective contraception for women - Progressive chronic disease - Ongoing psychiatric disorders - Current addiction to other substances or cessation of less than one year - Current treatment with psychotropic agents - Epilepsy and other contra-indications for rTMS (pacemaker, metallic clips or other electronic implants, head trauma, intracranial hypertension). - Contra-indications for transdermal nicotine substitutes (recent myocardial infarction, unstable or worsening angina, Prinzmetal angina, severe heart rhythm disorders, recent stroke, skin disorders that could interfere with the use of transdermal treatments, hypersensitivity to one of the constituents). - Personnel working in the psychiatric and addictology unit of the CHU (conflict of interest) |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Centre Hospitalier Universitaire | Dijon |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire Dijon |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from Baseline score of Tabacco Craving Questionnaire (TCQ) | at Week 0, Week 1, Week 2, Week 6 and Week 12 after stimulation | Yes |
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