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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02812810
Other study ID # TROJAK DRCI 2010
Secondary ID
Status Completed
Phase N/A
First received June 20, 2016
Last updated June 22, 2016
Start date September 2011

Study information

Verified date June 2016
Source Centre Hospitalier Universitaire Dijon
Contact n/a
Is FDA regulated No
Health authority France: Agence Nationale de Sécurité du Médicament et des produits de santé
Study type Interventional

Clinical Trial Summary

The fight against smoking is a public health priority. Without help, fewer than 5% of des smokers are abstinent at 12 months after smoking cessation.

Despite well-managed attempts at smoking cessation with nicotine substitutes, the rate of success at 12 months in patients dependent on nicotine is only 18%. Moreover, other therapeutic strategies (acupuncture, hypnosis…) have not proved to be effective.

The investigators propose a new therapeutic strategy for smoking cessation, which is based on associating nicotine substitutes (to reduce physical symptoms of weaning from nicotine) with rTMS at 1 Hz to the right DorsoLateral PreFrontal Cortex (DLPFC) for 2 weeks (to diminish craving for tobacco). The principal objective is to improve the success rate for smoking cessation attempts in patients who are highly dependent on nicotine, and who have failed using usual smoking cessation strategies.


Recruitment information / eligibility

Status Completed
Enrollment 39
Est. completion date
Est. primary completion date February 2015
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Adult 18-65 years old

- Wishing to stop smoking

- Highly dependent on nicotine (score = 7 on the Fagerström self-questionnaire)

- History of at least 2 failed attempts to stop smoking despite recommended treatments (nicotine, vareniciline, bupropion)

Exclusion Criteria:

- Abstinence in the 3 previous months

- Absence of effective contraception for women

- Progressive chronic disease

- Ongoing psychiatric disorders

- Current addiction to other substances or cessation of less than one year

- Current treatment with psychotropic agents

- Epilepsy and other contra-indications for rTMS (pacemaker, metallic clips or other electronic implants, head trauma, intracranial hypertension).

- Contra-indications for transdermal nicotine substitutes (recent myocardial infarction, unstable or worsening angina, Prinzmetal angina, severe heart rhythm disorders, recent stroke, skin disorders that could interfere with the use of transdermal treatments, hypersensitivity to one of the constituents).

- Personnel working in the psychiatric and addictology unit of the CHU (conflict of interest)

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Device:
active rTMS

sham rTMS


Locations

Country Name City State
France Centre Hospitalier Universitaire Dijon

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change from Baseline score of Tabacco Craving Questionnaire (TCQ) at Week 0, Week 1, Week 2, Week 6 and Week 12 after stimulation Yes
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