Smoking Cessation Clinical Trial
Official title:
Interventions for Tobacco Dependent Adolescents
Currently one in five high school students smokes. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems. This study will compare the effectiveness of treatment with bupropion, a nicotine patch, or nicotine gum in supporting the reduction of smoking in adolescent smokers.
Among adolescents, the short-term health effects of smoking include damage to the
respiratory system, addiction to nicotine, and the associated risk of other drug use.
Adolescents are at greater risk for long-term health problems because most young people who
smoke regularly continue to smoke throughout adulthood. This study will compare the
effectiveness of treatment with bupropion, a nicotine patch, or nicotine gum in supporting
the reduction of smoking in adolescent smokers. The study will also assess whether reduction
of smoking leads to continued involvement in treatment, less toxic cigarette exposure, and
improved motivation to quit.
This open-label study will last a total of 6 weeks. Baseline measurements will be taken
twice a week at study visits for the first two weeks to assess vital signs and smoking
behavior. Participants will aslo use a computerized device outside of study visits to
monitor their own smoking habits. At Week 3, participants will be randomly assigned to
receive bupropion, a nicotine patch, nicotine gum, or placebo. Participants will be asked to
limit the frequency of their smoking to 75% of what it was during baseline. During Weeks 4,
5, and 6, participants will be expected to reduce smoking behavior to 50% of what it was at
baseline. Customized doses of nicotine patches and nicotine gum, relative to the amount of
cigarettes a participant smoked during baseline, will be dispensed weekly. Participants
receiving bupropion or placebo will receive medication at each study visit and will take one
pill daily. During treatment, study visits will occur once weekly. At each study visit, all
participants will receive a 10- to 15-minute standardized behavioral therapy session aimed
at supporting smoking reduction. Smoking habits and vital signs will be assessed and the
effects of the treatments will be determined. There will be one follow-up visit 3 months
post-intervention, at which time smoking status will be assessed.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03999411 -
Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients
|
Phase 4 | |
Completed |
NCT04043728 -
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study
|
N/A | |
Completed |
NCT04617444 -
The ESTxENDS Trial- Substudy on Effects of Using Electronic Nicotine Delivery Systems (ENDS) on Olfactory Function
|
N/A | |
Completed |
NCT02796391 -
Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
|
Phase 2 | |
Completed |
NCT03397511 -
Incorporating Financial Incentives to Increase Smoking Cessation Among Asian Americans Residing in New York City
|
N/A | |
Not yet recruiting |
NCT05188287 -
A Culturally Tailored Smartphone Application for African American Smokers
|
N/A | |
Recruiting |
NCT05264428 -
The Effect of Honey on Lessening the Withdrawal Symptoms
|
N/A | |
Recruiting |
NCT05846841 -
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
|
N/A | |
Completed |
NCT04133064 -
Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study
|
N/A | |
Completed |
NCT03187730 -
Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants
|
Phase 4 | |
Completed |
NCT03474783 -
To Explore the Factors Affecting the Effectiveness of Smoking Cessation
|
N/A | |
Completed |
NCT04635358 -
Feasibility Study of Smoking Cessation for the Staff of a Hospital Center
|
N/A | |
Terminated |
NCT03670264 -
BE Smokefree: Behavioral Economics Incentives to Engage Adolescents in Smoking Cessation
|
N/A | |
Not yet recruiting |
NCT06307496 -
VIDeOS for Smoking Cessation
|
N/A | |
Completed |
NCT02905656 -
Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit
|
N/A | |
Completed |
NCT02997657 -
Positive Psychotherapy for Smoking Cessation Enhanced With Text Messaging: A Randomized Controlled Trial
|
N/A | |
Completed |
NCT03206619 -
A Health Recommeder System to Tailor Message Preferences in a Smoking Cessation Programme
|
||
Completed |
NCT02239770 -
Pharmacokinetics of Nicotine Film in Smokers
|
N/A | |
Completed |
NCT02562521 -
A Smoking Cessation Intervention for Yale Dining Employees
|
Phase 4 | |
Recruiting |
NCT02422914 -
Benefits of Tobacco Free Cigarette
|
N/A |