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Smokeless Tobacco clinical trials

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NCT ID: NCT03998735 Recruiting - Smokeless Tobacco Clinical Trials

Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure

Start date: October 19, 2021
Phase: Phase 1
Study type: Interventional

Our goal in this study is to investigate the extent of endogenous nitrosation of nornicotine in smokeless tobacco users as a function of nornicotine content in smokeless products. This study will lead to an understanding of the endogenous formation of NNN from nornicotine in humans, and will also investigate the effect of the reduction of nornicotine content in smokeless tobacco on the extent of endogenous NNN formation. The knowledge gained in this study will lead to the development of recommendations for the regulation, or potentially elimination, of nornicotine in smokeless tobacco products in order to minimize exposure to NNN in the users of these products.

NCT ID: NCT02994082 Active, not recruiting - Nicotine Dependence Clinical Trials

Treating Smokeless Tobacco Use in Rural Veterans

Start date: December 2016
Phase: N/A
Study type: Interventional

This is a pilot study designed in an effort to develop and improve access to effective treatments for tobacco use in rural Veterans using a tailored intervention approach. Specifically, we will evaluate a combined behavioral and pharmacological smokeless tobacco cessation which concomitantly addresses comorbid issues commonly experienced by rural tobacco users including elevated depressive symptoms, risky alcohol use, and concerns about weight gain. The objectives are to: 1. Evaluate the feasibility of an individually-tailored telephone intervention for rural smokeless tobacco users 2. Examine the impact of the intervention on treatment utilization, patient satisfaction, and smokeless tobacco cessation.

NCT ID: NCT01369693 Completed - Smoking Cessation Clinical Trials

In-vivo Extraction of Pb, Cd and TSNA From Swedish Snus

SMWS03
Start date: May 2004
Phase: Phase 1
Study type: Interventional

In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini". Each portion of used snus will be collected and frozen (-20 oC) pending analysis of lead (Pb), cadmium (Cd), nicotine and tobacco specific nitrosamines (TSNAs). Unused snus is collected and deep frozen for analysis and calculation of extracted dose. Calculations of extracted amount of lead, cadmium, nicotine and tobacco specific nitrosamines (TSNAs) respectively, will be done for each type of snus.

NCT ID: NCT01249339 Completed - Smoking Cessation Clinical Trials

In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus

SMWS03
Start date: May 2004
Phase: Phase 1
Study type: Interventional

In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini". Each portion of used snus will be collected and frozen (-20 oC) pending analysis of lead (Pb), cadmium (Cd), nicotine and tobacco specific nitrosamines (TSNAs). Unused snus is collected and deep frozen for analysis and calculation of extracted dose. Calculations of extracted amount of lead, cadmium, nicotine and tobacco specific nitrosamines (TSNAs) respectively, will be done for each type of snus.

NCT ID: NCT01100216 Withdrawn - Smokeless Tobacco Clinical Trials

Human Laboratory Study of Smokeless Tobacco Products

Start date: March 2010
Phase: N/A
Study type: Interventional

With the advent of restrictions on public smoking, the tobacco industry has introduced a variety of novel smokeless tobacco products (NSTP) to allow continued tobacco use. These products typically have lower tobacco-specific nitrosamines, carcinogens and nicotine than conventional smokeless products out on the market. No studies have compared the effects of NSTP and medicinal nicotine products (MNP) in smokeless tobacco users and whether some of the NSTP products may serve as a cessation tool for smokeless tobacco users. Our hypothesis is that the effects from these products will be directly related to their nicotine content and sensory effects. Products that produce greater effects on outcome measures may serve as potential cessation tools.

NCT ID: NCT00414180 Completed - Smokeless Tobacco Clinical Trials

Bupropion SR for Treating Smokeless Tobacco Use

Start date: August 2003
Phase: Phase 3
Study type: Interventional

To determine the efficacy and safety of bupropion SR for quitting tobacco in smokeless tobacco users.

NCT ID: NCT00265681 Completed - Clinical trials for Tobacco Use Cessation

Telephone Counseling for Snuff Users

Start date: November 2004
Phase: N/A
Study type: Interventional

The primary objective is to evaluate the effectiveness of telephone-based counseling in promoting smokeless tobacco cessation among residents of Minnesota. It is hypothesized that a greater proportion of individuals assigned to the proactive telephone calls will quit their use of smokeless tobacco products and all tobacco products compared to the comparison group not receiving those calls.