Small Intestine Problem Clinical Trial
Official title:
Metabolomics in Small Intestinal Bacterial Overgrowth
Small intestinal bacterial overgrowth (SIBO) is a condition where a person's own good and
useful germs, live in parts of the bowel where there should not be any germs. It may cause
difficult tummy and bowel symptoms in a wide variety of patient groups. Increasing evidence
suggests that sometimes small intestinal bacterial overgrowth can also trigger or worsen
diseases which do not have any bowel symptoms at all.
It is hugely under-diagnosed in clinical practice. Part of the reason for this is that
current available diagnostic tests - culture of fluid sampled from the upper part of the
gastrointestinal tract or breath testing, are complicated to do, difficult for the patient,
and are not completely accurate. Therefore, the potential for a simple, more accurate test to
revolutionise the diagnosis and aid with the treatment of this condition is immense.
When it is accurately diagnosed, treatment with antibiotics can cure the patient of their
tummy or bowel symptoms.
Based on previous research the investigators have conducted, it is believed that it might be
possible to diagnose this condition in a simpler and more accurate way by examining urine
samples. This study will also investigate whether the condition could be diagnosed more
accurately using a blood test, a different sort of breath test or using a mouth swab.
The proposed study will be conducted at Lincoln County Hospital, in collaboration with Joseph
Banks Laboratory at the University of Lincoln. Additional urine, blood, swab and breath
samples from patients with and without small intestinal bacterial overgrowth, before and
after antibiotic treatment to identify specific molecular markers in urine, blood and saliva
samples which diagnosis small intestinal bacterial overgrowth accurately.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02720848 -
Double/Single Balloon Enteroscopy Stiffening Wire RCT
|
N/A |