Small Intestine Cancer Clinical Trial
Official title:
Assessment of an Optimized and Standardized Computerised Tomography (CT) Reading Grid for Preoperative Planning Improvement of Small Bowel Neuroendocrine Tumours (NET).
Neuro-endocrine tumours (NET) are the most frequent tumours of the small intestine. In spite
of their small size, these tumours have the particularity of forming mesenteric metastasis
and ganglionic secondary lesions along the superior mesenteric axis, which is in close
proximity to the superior mesenteric artery (SMA).
Surgery is the only curative treatment. The complete resection being a factor for good
patient prognosis, risks of subsequent local complications (occlusion, bleeding) must be
discussed. The limiting factor for resectability is arterial vascular invasion considering
the risk of postoperative small bowel syndrome.
At the moment, the choice of imaging examination and its protocol is not standardized, nor
the description of the tumoral mesenteric and ganglionic extension, especially the criteria
defining a lymph node as lymphadenopathy. In addition, the complexity of SMA's anatomy and
the absence of criteria for arterial invasion defining arterial invasion may lead to a
misinterpretation of the preoperative imaging , and thus to an incomplete planning of the
surgical procedure.
To correct this absence of radiological standardization, the investigating team has developed
a reading grid for Computed Tomography (CT) aimed to facilitate preoperative planning of
small bowel NET.
The main objective of the current study is to improve the semiotic description of the
mesenteric and ganglionic tumoral extension of small intestine NET using a technically
optimized imaging examination and a standardized reading grid in order to plan the best
surgical procedure which would allow maintaining a minimal length of small intestine needed
to yield a satisfying quality of life and nutritional status.
The secondary objective of this study is to evaluate the reproducibility of the standardized
scanner's reading grid.
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