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Small Fibre Neuropathy clinical trials

View clinical trials related to Small Fibre Neuropathy.

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NCT ID: NCT03830762 Completed - Clinical trials for Peripheral Neuropathy

Xanamemâ„¢ in Healthy Elderly Subjects

XanaHES
Start date: January 21, 2019
Phase: Phase 1
Study type: Interventional

Xanamemâ„¢ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body. It is believed that reducing the level of cortisol will be a benefit in the treatment of Alzheimer's disease. The XanaHES study is testing the safety and tolerability of Xanamem. It is planned to enrol approximately 84 participants, male and female aged from 50 to 75 who are in good health, in the study at 1 centre in Australia. The XanaHES Phase I study is a single-blind study. Subjects will be randomised to receive either 20mg once daily Xanamem or Placebo in cohort 1. Once all subjects have completed the study treatment of 12 weeks, a dose escalation committee will decide if a new cohort, cohort 2, with 30mg once daily vs placebo is started.

NCT ID: NCT01160887 Completed - Diabetes Mellitus Clinical Trials

Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study

Start date: June 2010
Phase: N/A
Study type: Observational

The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy. The model will shed light on aspects of peripheral nerve injuries on both somatic and as well as visceral sensory nerves. Classical autonomic parameters from electrocardiography (ECG) and Holter (24-h ECG and blood pressure) are compared with peripheral nerve injuries. The damage of autonomic nerves often recognized late in the course when patients develop gastroparesis, however an earlier recognition of this nerve damage may help clarifying the fundamental pathomechanisms and thereby optimize treatment for this patient group in the future.