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Clinical Trial Summary

The study treatment will consist of a platinum drug (carboplatin or cisplatin per investigator's choice) plus etoposide plus durvalumab plus monalizumab every 3 weeks for 4 cycles. After 4 cycles, subjects will continue maintenance treatment with durvalumab plus monalizumab every 4 weeks until disease progression, unacceptable toxicity, decision to stop study treatment, or withdrawal of consent. Patients who have received one prior cycle of treatment before enrolling on the study will receive a total of 4 cycles with monalizumab, durvalumab, and chemotherapy. There will be a safety lead-in phase, including 6 to 12 patients, to confirm the safety of the proposed dose of monalizumab to use in combination with chemotherapy and durvalumab.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05903092
Study type Interventional
Source Hoosier Cancer Research Network
Contact Hirva Mamdani, MD
Phone 313-576-8711
Email mamdanih@karmanos.org
Status Recruiting
Phase Phase 2
Start date September 26, 2023
Completion date June 30, 2025

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