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Molecular Profiling in Small Cell Lung Cancer — MPSCLC  

Small Cell Lung Cancer Clinical Trial

Official title:
Prospective Molecular Profiling in Small Cell Lung Cancer

Clinical Trial Summary

This protocol is to obtain tumor tissues and blood samples from patients with a confirmed histological diagnosis of Small cell lung cancer(SCLC) for molecular profiling.

Clinical Trial Description

Small cell lung cancer (SCLC) is most invasive subtypes of lung cancer. After diagnosis, the SCLC patients without treatment often die in 2-4 months. SCLC is a highly heterogeneous malignant tumor, the previous treatment principle of the tumor is based on the traditional histopathology, which not provide accurate guidance for precise treatment. In recent years, breakthrough has been made in molecular classification of breast cancer, non-small cell lung cancer, gastrointestinal cancer and of the other tumor, but SCLC molecular classification has not yet reported.

In this prospective study, SCLC tissues and blood samples from extensive SCLC patients will be obtained and evaluated of molecular profiling. Eligible population includes: patients who have not undergone any treatment and diagnosed of extensive SCLC by immunohistochemistry(IHC). The purpose is to evaluate molecular profiling of SCLC patients who are sensitive or resistant to chemotherapy (Cisplatin+Etoposide). To compare molecular alterations of SCLC patients with different prognosis (Overall Survival, Progress Free Survival). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03162705
Study type Observational
Source Zhujiang Hospital
Contact Qiongyao Wang
Phone 86-13560101028
Email qiongyaow@163.com
Status Recruiting
Phase
Start date May 3, 2017
Completion date December 31, 2021
View Details
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