Immunotherapy as Second-line in Patient With Small Cell Lung Cancer

Status Completed

Clinical Trial Summary

Chemotherapy still constitutes the backbone of small-cell lung cancer (SCLC) therapy, particularly in the extensive disease (ED) stage (ED-SCLC). Despite the fact that a substantial complete response rate could be achieved in SCLC patients receiving etoposide - cisplatin doublet, cure remains the exception. Overall survival in patients receiving this combination is 10 months and progression free survival 6.3 months. At time of progression two options are hitherto accepted: reinduction of carboplatin - etoposide doublet or, for patients unfit for reinduction, topotecan single-drug regimen. However, in both clinical cases, median survival hardly achieves 33 weeks. Consistent data using anti - PDL1 (Programmed death-ligand 1) or anti PD1 (programmed cell death 1) antibodies suggest that they are active as single drug regimens in many malignant diseases. Taking into account the rich tumor infiltrating lymphocyte in pathological specimens of SCLC, we can hypothesize that experimental use of ATEZOLIZUMAB (MPDL3280A) in patients is ethical pending that it demonstrates activity in the second line setting.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Lung Neoplasms
Small Cell Lung Cancer
Small Cell Lung Cancer Extensive Stage
Small Cell Lung Cancer Limited Stage
Small Cell Lung Carcinoma

Clinical Trial Details

NCT number	NCT03059667
Study type	Interventional
Source	Intergroupe Francophone de Cancerologie Thoracique
Contact
Status	Completed
Phase	Phase 2
Start date	March 13, 2017
Completion date	December 1, 2020

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See also
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