Slow Transit Constipation Clinical Trial
Official title:
Characterization of Intestinal Microbiota in Constipation Patients: Using 16S rRNA Gene Sequencing Analysis
Constipation is a frequent, chronic gastroenterological problem that has many varied
symptoms and thus has several clinical definitions. According to the Rome III criteria for
chronic constipation, almost 16% of all adults are affected by chronic constipation
worldwide, and it is more prevalent and symptomatic in women and elderly people. Slow
transit constipation (STC) is the major category and is characterized by a decreased rate of
colonic transit.
Recently, many researchers have focused on the relationship between intestinal microbiota
and constipation and have demonstrated that intestinal microbiota contribute to the
pathophysiology of functional gastrointestinal disorders.
Thus, there is a need for an improved understanding of gut microbiota composition in
constipation patients and for the potential role played by the gut microbiota in the
etiology of STC.To achieve this goal the investigators characterized and compared the
intestinal microbiota among carefully selected patients with constipation that were
clinically categorized based on Rome III criteria, and healthy controls using high
throughput pyrosequencing of the 16S rRNA gene and a conservative approach to detect
quantitative changes in the relative abundances of taxa.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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