Slow Transit Constipation Clinical Trial
Official title:
A Randomized Controlled Study of Efficacy, Safety and Durability of Fecal Microbiota Transplantation in Adult Patients With Slow Transit Constipation
The purpose of this study is to evaluate the effect of fecal microbiota transplantation in adults with slow transit constipation.
Constipation is a chronic disease estimated to affect about 10% - 15% of the worldwide
general population. Constipation frequency appears to augment with increasing age,
particularly after 65 years old.
Recent evidence in the literature and collected in the investigators' laboratory confirm
that constipation can be a consequence of intestinal dysbiosis, with an increase of
potentially pathogenic microorganisms and a decrease of potentially beneficial
microorganisms. These alterations may affect the motility and metabolic environment of
colon, especially the production of short chain fatty acids (SCFAs).
A new and under-explored method to manipulate the gastrointestinal microbiota involves fecal
microbiota transplantation (FMT). There has been growing interest in the use of fecal
microbiota for the treatment of patients with chronic gastrointestinal infections (e.g. CDI)
and other extraintestinal conditions (e.g. IBD). Similarly, the investigators suppose that
reshaping the gut microbiome with FMT would be effective for patients with slow transit
constipation.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02844426 -
Effect of a Synbiotic on Symptoms of Patients With STC
|
Phase 2 | |
| Recruiting |
NCT05352074 -
STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation
|
N/A | |
| Recruiting |
NCT02291354 -
Evaluating the Synergism of Soluble Dietary Fiber With Fecal Microbiota Transplantation in Slow Transit Constipation
|
Phase 2 | |
| Active, not recruiting |
NCT02301221 -
Effect of Fecal Microbiota Transplantation in Slow Transit Constipation
|
Phase 2 | |
| Active, not recruiting |
NCT05718505 -
Comparison of the Atmo Motility Gas Capsule System to the Reference Standard
|
N/A | |
| Recruiting |
NCT02676388 -
Freeze-dried vs Fresh Fecal Microbiota Transplantation in Patients With Slow Transit Constipation
|
Phase 2 | |
| Recruiting |
NCT02984969 -
Using 16S rRNA Gene Sequencing Analysis Intestinal Microbiota in Constipation Patients
|
N/A |