Skeletal Health in Bariatric Surgery Patients

Osteoporosis Clinical Trial

Official title: Skeletal Health in Bariatric Surgery Patients

Status Completed

Clinical Trial Summary

The investigators propose a prospective cohort trial that will help to understand the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal female bariatric patients.

Clinical Trial Description

While highly effective both RYGB and SG may lead to increased bone resorption, decreased bone mass, and increased risk of some fractures. Very few studies have compared the effects of the RYGB and the SG on changes skeletal health and findings have been inconsistent. Furthermore, few studies have investigated the short- or long-term consequences of bariatric surgery on bone mineral density in pre- and post-menopausal women. To what extent and how bariatric surgery impacts the skeleton largely remains undetermined. Because estrogen is protective against osteoporosis and fractures, the majority of fractures occur in postmenopausal women. It is important that women have higher rates of obesity (38.3%) compared to men (34.3%) and that ≥67% of bariatric patients are women. Therefore, women may be at a significantly increased risk of developing osteoporosis. These data may help establish clinical guidelines to assess, maintain, and promote skeletal health in the preoperative and postoperative care of bariatric patients; and it may help to determine the appropriate bariatric procedure for women at risk of osteoporosis and fractures. ;

Related Conditions & MeSH terms

• Bariatric Surgery
• Fractures, Bone
• Menopause
• Osteoporosis
• Premenopause
• Roux En-Y Gastric Bypass
• Sleeve Gastrectomy

• NCT number: NCT03331536
• Study type: Observational
• Source: University of Alabama at Birmingham
• Status: Completed
• Start date: March 22, 2018
• Completion date: August 2, 2020