Dose-dependent Impact of Daytime Lighting on Evening Responses to Light

Sleep Clinical Trial

Official title:

Dose-dependent Impact of Daytime Lighting on Evening Responses to Light

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04882280
• Other study ID #: Reverse DRC
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 2022
• Est. completion date: July 2024

Study information

• Verified date: March 2022
• Source: VA Palo Alto Health Care System
• Contact: Jamie Zeitzer, PhD
• Phone: 6504935000
• Email: jzeitzer[@]stanford.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to systematically examine the impact of different intensities of daytime light and the subsequent impact that such exposure has on non-image forming responses to light in the evening.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 48
• Est. completion date: July 2024
• Est. primary completion date: June 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Aged 18-65

2. Good health

3. Male or female

4. Normal color vision

Exclusion Criteria:

1. Sleep disorders

2. Extreme chronotypes

3. Routine smoker

4. Significant hearing loss

5. Depressed

6. Alcohol use disorder

7. Use of illegal drugs

Related Conditions & MeSH terms

• Sleep

Intervention

Behavioral:
• Light
10 hours of light exposure during the daytime, starting 2 hours after habitual wake time

Locations

Country	Name	City	State
United States	VA Palo Alto Health Care System	Palo Alto	California

Sponsors (1)

Lead Sponsor	Collaborator
Palo Alto Veterans Institute for Research

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Suppression of melatonin production	Difference in salivary melatonin concentrations between active arm and 3 lux control condition	4 hours
Primary	Phase shift in the timing of melatonin onset	Change in the onset of melatonin secretion after experimental stimulus	2 days