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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03368352
Other study ID # 170200
Secondary ID
Status Completed
Phase Early Phase 1
First received
Last updated
Start date July 4, 2017
Est. completion date December 20, 2018

Study information

Verified date January 2019
Source University of California, San Diego
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep. Low oxygen itself and the induced oxidative stress can damage mental function which is likely worsened by poor sleep. Reduced mental function due to low oxygen can pose a serious danger to mountain climbers. However there is also mounting evidence that even in populations of people that live at high altitudes and are considered adapted, low oxygen contributes to reductions in learning and memory. Therefore there is a serious need for treatments which may improve sleep, control of breathing and mental function during low oxygen. Melatonin is a hormone produced in the brain during the night which regulates sleep patterns with strong antioxidant and anti-inflammatory properties. A study previously reported that melatonin taken 90 mins before bed at 4,300 m (14,200 ft) induced sleep earlier, reduced awakenings and improved mental performance the following day. However how melatonin caused these effects was not determined. Therefore this study aims to determine how melatonin effects control of breathing, sleep and mental performance during exposure to low oxygen.


Recruitment information / eligibility

Status Completed
Enrollment 20
Est. completion date December 20, 2018
Est. primary completion date December 20, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

Exclusion Criteria:

- Sleep disorders

- Pregnant females

- Smokers (quit = 1 year ago acceptable)

- Any known cardiac (apart from treated hypertension with acceptable drugs, see below), pulmonary (including asthma), renal, neurologic (including epilepsy), neuromuscular, hepatic disease, or patients with diabetes.

- Prior or current use of melatonin.

- Use of any medications that may affect sleep or breathing, blood-thinning medications (anticoagulants), antioxidants, anti-inflammatories, medications that suppress the immune system (immunosuppressants), diabetes medications and birth control pills.

- A psychiatric disorder, other than mild depression; e.g. schizophrenia, bipolar disorder, major depression, panic or anxiety disorders.

- Substantial alcohol (>3oz/day) or use of illicit drugs.

- Previous occurrence of high altitude pulmonary or cerebral edema.

- Recent exposure to altitude (>8000ft) in the last month or having slept at an altitude >6000ft in the last month.

- Inability to provide written informed consent or able to complete the experiment.

- Non-English speakers (necessary to complete neurocognitive testing).

- More than 10 cups of beverages with caffeine (coffee, tea, soda/pop) per day.

Study Design


Intervention

Dietary Supplement:
Melatonin
Dietary supplement melatonin
Other:
Hypoxia
Sleep in a hypoxic tent simulating high altitude

Locations

Country Name City State
United States UCSD Sleep Lab San Diego California

Sponsors (1)

Lead Sponsor Collaborator
University of California, San Diego

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Neurocognitive function Stroop-color word test median number of errors. Higher numbers indicate worse performance. 30 minutes after arousal from sleep
Primary Endothelial function Reactive hypermedia index via EndoPat 5 minutes after arousal from sleep
Primary Lipid peroxidation in serum Concentration of Malondialdehyde in serum samples immediately after arousal from sleep
Primary Hypercapnic hypoxic ventilatory sensitivity This is the one outcome. It is the gain of the ventilatory response to changes in CO2, during sustained hypoxia. Delta minute ventilation / delta mmHg CO2 during sustained hypoxia 1 hour after arousal from sleep
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