Sleep Clinical Trial
Official title:
The Effects of Bright Light Exposure on ICU Nurses
Verified date | December 2018 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In the majority of intensive care units, nurses work 12 hour shifts that consist of days and
nights. Shift work outside of 6am-6pm has been reported to cause fatigue, induce sleep
disorders, and cause metabolic disturbances. This shift to a nocturnal 'day' rather than
diurnal, can result in reduced work performance, processing errors, accidents at work,
absenteeism, and reduced quality of life. More chronically, those working at night have been
shown to experience higher risks of heart disease, cancer and shorter median durations of
life span. Much of this elevated risk is thought to be due to altered exposure to light, the
dominant environmental cue regulating our circadian rhythms.
As diurnal organisms much of our biology is regulated by the solar day. Acutely, bright light
exposure (i.e., sun) regulates the phase of the biological clock principally through the
suppression of melatonin, which biologically mediates increased alertness and in essence,
'our daytime alertness'. During the night melatonin gradually increases and induces tiredness
and ultimately sleep. This, in part, is biology behind the use of melatonin in those with
sleep disturbances or to mitigate jet lag, with cross-continental or transoceanic flights.
In this study, the investigators will randomize nurses in the hospital to receive either high
intensity white light (3,000 lux) or standard ambient white fluorescent (~400 lx) light for
10 hours during their night shift. This high illuminance light, rich in blue spectrum, is
what diurnal creatures, like humans, are exposed to during the day. The lights may
subsequently be equipped with blue filters (442 nm) to heighten the exposure to the rich blue
spectrum light. Exposure will commence at the beginning of the night shift (~7pm) and
continue for 10 hours. The rationale for terminating exposure prior to shift end is to foster
an onset of sleep biology. At the end of each shift, the nurses will complete the Stanford
Sleepiness Scale and the Psychomotor Vigilance Task (PVT). Saliva samples will be collected
for melatonin level analysis and the nurses will complete sleep diaries at home. The
investigators hypothesize that exposure to high intensity lighting during night shifts will
reduce fatigue and enhance alertness and computational capacity that correlates with reduced
melatonin.
Status | Completed |
Enrollment | 31 |
Est. completion date | December 31, 2017 |
Est. primary completion date | December 1, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - All ICU nurses working at the University of Pittsburgh Trauma ICU. Exclusion Criteria: - Not working nights |
Country | Name | City | State |
---|---|---|---|
United States | Matthew R. Rosengart | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Psychomotor Vigilance Task | This test is the standard objective measure of alertness and wakefulness. It has been employed as a marker of attention deficit in hundreds of studies to date. It is a 10 minute test in which the subjects look at a small rectangular screen and press the mouse every time a bright circle appears. The number of lapses (responses greater than 500 ms) is recorded. | Immediately at the end of the night shift worked. | |
Primary | Stanford Sleepiness Scale | It was developed by Hoddes et al (1973) and is a simple 7-point rating scale. The scale is well validated and has been used in over 100 clinical trials. | Immediately at the end of the night shift worked. | |
Secondary | Consensus Sleep Diary | The Consensus Sleep Diary was developed in 2012 by a collaboration of insomnia experts. The subject will record what time they got into bed, time they went to sleep, how long to fall asleep, how many times they woke up, time they finally woke up, time they got out of bed, rate the quality of sleep, and how rested or refreshed they felt. | Throughout the course of the study for the night immediately following the night shift worked. | |
Secondary | Salivary melatonin concentration | A saliva sample will be obtained immediately following the night shift worked. It will be assayed for melatonin concentration | Immediately at teh end of the night shift worked. |
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