Sleep Clinical Trial
Official title:
Effect of Sleep Restriction on Metabolic Disturbances Caused by Overfeeding
The purpose of this study is to determine if sleep restriction provokes an increase in risk factors for metabolic diseases, such as elevation of ectopic fat and decreased sensitivity to insulin. We propose to evaluate the effect of sleep restriction in a model of metabolic challenge (overfeeding) caricaturing the conditions of modern societies everyday life .
General hypothesis :
In overfeeding condition, the stress response generated by partial sleep restriction of six
days will induce an accumulation of fat in the liver and a decreased insulin sensitivity of
adipose tissue , liver and muscle, more pronounced that in overfeeding condition only,
provoked by a deregulation of the nocturnal lipolysis .
Specific goals :
Purpose 1 : To measure the accumulation of fat in the liver (measured by nuclear magnetic
resonance ) and the tissue insulin sensitivity ( measured by a test meal ) in response to a
sleep restriction in overfeeding condition .
Hypothesis 1: In overfeeding condition (130 % of energy requirements ) , hepatic lipid
accumulation will be higher after 6 days of sleep restriction (4 hours per night) compared
to a control condition (8 hours of sleep per night ) . Decreased sensitivity to insulin in
the liver, adipose tissue and the associated muscle will be associated at this ectopic fat
accumulation.
Purpose 2 : To determine the alteration of lipolysis in response to sleep restriction in
overfeeding condition.
Hypothesis 2: In overfeeding condition, sleep restriction will increase the concentrations
of circulating fatty acids and glycerol in relation to condition of normal sleep.
;
Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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