Sleep Clinical Trial
Official title:
Effect of Sleep Timing, Independent of Duration, on Food Intake and Metabolic Control of Energy Balance
The purpose of this study is to test the effects of sleep and meal timing, independent of
sleep duration, on glucose regulation and metabolic and hormonal control of energy balance
in normal weight adults.
This study will be a 4-phase, randomized controlled study of 5 days each in which
participants will undergo 2 phases of late sleep times that differ in meal timing (normal or
late) and 2 phases of normal sleep times that differ in meal timing (normal or late).
The Aims and Hypotheses of this study are:
Aim 1: To compare hormonal regulation of food intake and metabolic risk markers in response
to altered sleep and meal timing.
- Hypothesis 1: There will be an interaction between sleep and meal time on glucose,
insulin, and glucose and insulin area under the curve after the glucose tolerance test
such that the late sleep/late meal will result in the worst metabolic profile, normal
sleep/late meal and late sleep/normal meal will have an intermediate profile, and
normal sleep/normal meal will result in the best metabolic profile.
- Hypothesis 2: There will be an interaction between sleep and meal time on leptin and
ghrelin concentrations such that the late sleep/late meal timing phase will result in
low leptin/high ghrelin, normal sleep/late meal timing and late sleep/normal meal will
have an intermediate profile, and normal sleep/normal meal timing will result in high
leptin/low ghrelin.
Aim 2: To compare food intake over a 24-h period in response to altered sleep and meal
timing.
• Hypothesis 3: Energy and fat intakes will be greater during the late sleep timing phase
compared to normal sleep timing.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
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