Sleep Clinical Trial
Official title:
Restorative Sleep: Effect of Dexmedetomidine
The purpose of this study is to determine whether an intravenous infusion of dexmedetomidine administered to surgical patients intra-operatively will improve the characteristics of sleep post-operatively.
Physiological similarities exist between the anesthetized state and sleep. Pathways within
the brain controlling sleep and wakefulness are also affected by anesthesia. One significant
difference between the states of anesthesia and sleep is the ability to respond whenever a
relatively mild stimulus is applied, e.g. verbal command or gently shaking. Interestingly,
this feature of arousability is seen when dexmedetomidine is used for sedation but is absent
when alternative intravenous anesthetic agents, e.g. propofol, are used to provide similar
degree of sedation. Recent studies have shown that dexmedetomidine acts on receptors located
within the locus ceruleus, which are responsible for both sleep and anesthesia.
During a recent study volunteers received an infusion of dexmedetomidine during the
afternoon prior to remaining under study conditions for the duration of the night. The study
was not designed to measure sleep but anecdotal reporting from the participants suggested
that they were able to resume their normal day's activities whilst the subject receiving
placebo felt extremely fatigued from lack of sleep. This prompted the establishment of a
pilot study to determine if dexmedetomidine could provide restorative sleep to people under
disturbed sleep conditions i.e. postoperative patients.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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