Sleep Deprivation Clinical Trial
Official title:
Study of Identification of Metabolomics-based Sleepiness Markers for Risk Prevention and Traffic Safety
Estimating that people sleep on average up to two hours less over the last decades, sleepiness and fatigue need to be considered as significant societal problems of the modern world. Jurisdiction is precise on how to deal with overtired offenders since they were not allowed to use machines or vehicles in the first place, similar to drunk individuals or consumers of illicit drugs. In contrast to alcohol or illicit drug use, however, there are no quick roadside or workplace tests as objective (analytical) biomarkers for sleepiness. Investigators hypothesize that increasing sleep drive or impaired wakefulness can be assessed by qualitative or quantitative fluctuations of certain metabolites in biological specimens, e.g., accumulation or decrease of endogenous substances related to sleep debt. Thus, this sleep study provides the necessary biological samples of either sleep-deprived, sleep-restricted, or control subjects, which are then analysed for appropriate metabolite biomarkers utilizing an untargeted metabolomics approach. In addition to established impairment tests, a state of the art driving simulator will be employed to objectively measure driving performance under all study conditions. Participants will also rate their subjective sleepiness using validated questionnaires.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05956886 -
Sleep Chatbot Intervention for Emerging Black/African American Adults
|
N/A | |
| Completed |
NCT02996864 -
Location-based Smartphone Technology to Guide College Students Healthy Choices Ph II
|
N/A | |
| Completed |
NCT03129204 -
Sensation Awareness Focused Training for Spouses
|
N/A | |
| Withdrawn |
NCT04049682 -
Start Times and Restful Sleep
|
||
| Completed |
NCT03182413 -
Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation
|
Phase 1 | |
| Not yet recruiting |
NCT01930279 -
Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood
|
N/A | |
| Completed |
NCT01989741 -
Effect of Sleep Restriction on Decision Making and Inflammation
|
N/A | |
| Completed |
NCT00228215 -
Tips for Infant and Parent Sleep (TIPS)
|
N/A | |
| Completed |
NCT00123214 -
A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation
|
N/A | |
| Completed |
NCT00079664 -
Comparing Tai Chi Training to a Low-Stress Physical Activity to Enhance Sleep in Older Adults
|
Phase 1 | |
| Completed |
NCT04179838 -
Olfactory Contributions to Sleep-dependent Food Craving
|
N/A | |
| Not yet recruiting |
NCT05513339 -
Effect of Sleep Deprivation on Cognitive Function Among Cardiology Fellows
|
||
| Recruiting |
NCT05026541 -
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
|
N/A | |
| Withdrawn |
NCT04096261 -
The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease
|
||
| Recruiting |
NCT06017882 -
Combined Effects of Acute Sleep Restriction and Moderate Acceleration (+Gz) on Physiological and Behavioral Responses to High Mental Workload
|
||
| Completed |
NCT00179322 -
Effects of Sleep Deprivation and Recovery on Cognitive Functions
|
||
| Recruiting |
NCT06399939 -
The Function of Biphasic Sleep in Infants
|
N/A | |
| Not yet recruiting |
NCT06027047 -
Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)
|
||
| Completed |
NCT05162105 -
Quick Returns - Sleep, Cognitive Functions and Individual Differences
|
N/A | |
| Completed |
NCT03981770 -
Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery
|