Sleep Deprivation Clinical Trial
Official title:
Biomarkers and Altered Metabolic Pathways During Sleep Loss
NCT number | NCT04214184 |
Other study ID # | 133959 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | December 2, 2019 |
Est. completion date | July 31, 2024 |
This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivity. The investigators will also determine if changes in plasma metabolites can be used as a biomarker to discriminate between adequate versus insufficient sleep.
Status | Recruiting |
Enrollment | 46 |
Est. completion date | July 31, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: 1. 18-35 years old; men and women a. Equal numbers of women and men will be included. 2. Body Mass Index (BMI) of > 18.5 and <24.9. 3. Inactive to habitual moderate physical activity level (<5 days of exercise per week). 4. Sleep/wake history: habitual sleep duration less than 6 hours per night. 5. Altitude history: Potential participants must have lived at Denver altitude or higher for at least 3 months. Exclusion Criteria: 1. Any clinically significant unstable medical or surgical condition within the last year (treated or untreated). 2. Any clinically significant psychiatric condition, as defined by DSM-IV-TR. I 3. Any clinically significant sleep disorder. 4. Use of prescription medications/supplements within one month or need of these medications at any time during the study. 5. Symptoms of active illness (e.g., fever). 6. Uncorrected visual impairment 7. History of shift work in prior year or travel more than one time zone in three weeks prior to study. 8. Participants must be entirely drug-free of illicit drugs, medications, nicotine and herbal products for one month prior to study. 9. Blood donation in the 30 days prior to inpatient study. 10. Ovulating women will be selected on the basis of a history of regular menstrual cycle ranging in length from 25-32 days with a maximum of three days variation month-to-month. They will have no history of prior gynecological pathology, be at least 1 year post-partum, not breast-feeding and not pregnant (HCG pregnancy test at screening and upon admission to the inpatient protocol). |
Country | Name | City | State |
---|---|---|---|
United States | Sleep Wake Center--University of Utah | Salt Lake City | Utah |
Lead Sponsor | Collaborator |
---|---|
University of Utah | University of Colorado, Boulder |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Metabolomics-branched chain amino acids change from baseline | Investigators will measure the abundance of the branched chain amino acids (valine, leucine, isoleucine) in plasma at baseline and at post intervention. | Morning fasted blood will be collected for analyses at baseline and after the four week increased sleep duration intervention. | |
Primary | Insulin Sensitivity change from baseline | Investigators will measure insulin sensitivity using the oral glucose tolerance test in the morning after overnight sleep assessments in the lab, at baseline and after the four week increased sleep duration intervention. | Oral glucose tolerance testing will take about 3 hours to complete, and will be tested at baseline and after the four week increased sleep duration intervention. | |
Secondary | Untargeted Metabolomics change from baseline | Investigators can detect relative abundance of ~4,000 plasma metabolites. A combination of metabolites that can discriminate between adequate versus insufficient sleep will be identified as a potential biomarkers of insufficient sleep in free-living adults. | Morning fasted blood will be collected for analyses at baseline and after the four week increased sleep duration intervention. |
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