Sleep Deprivation Clinical Trial
Official title:
Biomarkers of Insufficient Sleep and Sleepiness
Sleep and wakefulness disorders impact 50 to 70 million Americans and insufficient sleep is epidemic with over 50% of Americans reporting less than 7 hours of sleep per night. Health problems associated with insufficient sleep include inflammation, depression and anxiety, diabetes, stress, drug abuse, poor quality of life, obesity, and fatigue related accidents on the job/while driving. While the contribution of sleep to overall health, well-being, and public safety is recognized, no established clinical biomarkers of sleep deficiency exist. Such biomarkers would have utility as road-side biomarkers of sleepiness (e.g., drowsy driving), monitoring on the job fatigue/fitness for duty (e.g., transportation, military ops health care), monitoring sleep health, as well as for clinical diagnostics and measures of clinical treatment outcomes. Thus, investigators designed a controlled laboratory insufficient sleep protocol utilizing metabolomics to identify biomarkers of insufficient sleep. Investigators propose to identify changes in metabolites that consistently occur during insufficient sleep. As an exploratory outcome investigators will examine associated changes in metabolites and cognitive performance during insufficient sleep.
Impaired sleep affects millions of people each year representing an important public health issue. This project will utilize metabolomics approaches to identify biomarkers in the blood that respond consistently to insufficient sleep. The overall goal of this project is to use a discovery and targeted approach to identify specific small molecules in plasma as candidate biomarkers of insufficient sleep. Investigators will conduct a controlled in-laboratory insufficient sleep protocol where participants receive 2 days of 5 hour sleep opportunities per night on 2 separate occasions. Plasma will be collected for metabolomics analyses every 2 hours (across 24 hours) during scheduled wakefulness at baseline and during insufficient sleep. Participants will complete the insufficient sleep protocol twice, separated by 23 days of sufficient sleep, to identify which plasma metabolites consistently change during insufficient sleep. Investigators anticipate these findings will be the first step in establishing validated biomarkers of impaired sleep that will advance our understanding, assessment and management of health consequences and symptoms associated with insufficient sleep. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05956886 -
Sleep Chatbot Intervention for Emerging Black/African American Adults
|
N/A | |
Completed |
NCT02996864 -
Location-based Smartphone Technology to Guide College Students Healthy Choices Ph II
|
N/A | |
Completed |
NCT03129204 -
Sensation Awareness Focused Training for Spouses
|
N/A | |
Withdrawn |
NCT04049682 -
Start Times and Restful Sleep
|
||
Completed |
NCT03182413 -
Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation
|
Phase 1 | |
Not yet recruiting |
NCT01930279 -
Effect of Partial Sleep Deprivation on Immunological System in Peripheral Blood
|
N/A | |
Completed |
NCT01989741 -
Effect of Sleep Restriction on Decision Making and Inflammation
|
N/A | |
Completed |
NCT00228215 -
Tips for Infant and Parent Sleep (TIPS)
|
N/A | |
Completed |
NCT00123214 -
A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation
|
N/A | |
Completed |
NCT00079664 -
Comparing Tai Chi Training to a Low-Stress Physical Activity to Enhance Sleep in Older Adults
|
Phase 1 | |
Completed |
NCT04179838 -
Olfactory Contributions to Sleep-dependent Food Craving
|
N/A | |
Not yet recruiting |
NCT05513339 -
Effect of Sleep Deprivation on Cognitive Function Among Cardiology Fellows
|
||
Recruiting |
NCT05026541 -
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
|
N/A | |
Withdrawn |
NCT04096261 -
The Importance of Sleep Quality and the Blood-brain Barrier in Cognitive Disorders and Alzheimer's Disease
|
||
Recruiting |
NCT06017882 -
Combined Effects of Acute Sleep Restriction and Moderate Acceleration (+Gz) on Physiological and Behavioral Responses to High Mental Workload
|
||
Completed |
NCT00179322 -
Effects of Sleep Deprivation and Recovery on Cognitive Functions
|
||
Recruiting |
NCT06399939 -
The Function of Biphasic Sleep in Infants
|
N/A | |
Not yet recruiting |
NCT06027047 -
Breakthrough Anxiety and Sleep Evaluation Using Linked Devices and Smartphone Application Onar (BASEL)
|
||
Completed |
NCT05162105 -
Quick Returns - Sleep, Cognitive Functions and Individual Differences
|
N/A | |
Completed |
NCT03981770 -
Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery
|