Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents

Sleep Deprivation Clinical Trial

Official title:

Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00272233
• Other study ID #: HIC26414
• Secondary ID: NIH NHLBI K24 04
• Status: Completed
• Phase: Phase 1
• First received: January 3, 2006
• Last updated: March 19, 2007
• Start date: December 2004
• Est. completion date: June 2005

Study information

• Verified date: January 2006
• Source: Yale University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Yale University School of MedicineUnited States: National Heart Lung and Blood Institute
• Study type: Observational

Clinical Trial Summary

Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function. The purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees.

Description:

Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown.

Objective: We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction.

Design: Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design.

Setting: University hospital medical intensive care unit

Patients or Other Participants: Twenty-two healthy medical residents were studied during a medical intensive care unit rotation.

Main Outcome Measure(s): Sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (C-reactive protein), and flow-mediated dilation in the brachial artery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: June 2005
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Medical resident in MICU rotation

• Non-smoker

• Body mass index <28 kg/m2

Exclusion Criteria:

• Systolic blood pressure >140 mmHg; Diastolic blood pressure >90 mmHg

• Known history of diabetes mellitus, hypertension, hyperlipidemia

• Known history of acute or chronic inflammatory or infectious disease

• Known history of sleep disturbance unrelated to work

• Pregnancy

Study Design

Observational Model: Defined Population, Time Perspective: Longitudinal

Related Conditions & MeSH terms

• Sleep Deprivation

Locations

Country	Name	City	State
United States	Yale University School of Medicine	New Haven	Connecticut

Sponsors (3)

Lead Sponsor	Collaborator
Yale University	National Center for Research Resources (NCRR), National Heart, Lung, and Blood Institute (NHLBI)

Country where clinical trial is conducted

United States,