Sleep Bruxism Clinical Trial
Official title:
The Efficacy of Gabapentine and Splint Therapy in Bruxers: a Randomized Clinical Trial
Sleep bruxism (SB) is defined as a "stereotyped movement disorder characterized by grinding
or clenching of the teeth during sleep" usually associated with sleep arousal. It might lead
to abrasive tooth wear, hypermobility of teeth, tooth hypersensitivity, hypertrophy of the
masticatory muscles and pain in the masticatory muscles.
Diagnostic procedures include clinical evaluation, ambulatory monitoring sleep laboratory
investigations and others. The clinical approach comprises the patient's history, orofacial
examination, and tooth wear classification.
There is no specific treatment for bruxism. Management of SB comprises psychological,
orodental and pharmacological strategies.Orodental therapies, including soft vinyl mouth
guards or stabilization bite splints, probably function more like protectors of the
orofacial structures rather than actually diminishing bruxism.Drug treatment of sleep
bruxism is controversial since different treatment strategies have resulted in suppression
or exacerbation of this condition.
Based on the current data, central primary efferents are the major drivers of bruxism.
Therefore centrally acting agents such as antiepileptic drugs which also affect the sleep
structure, might be effective on SB.
In a case report of bruxism, anxiety and tremor, the authors suggested that anti-convulsant
Gabapentine may be a useful treatment for patients with antidepressant-induced bruxism.
However in the absence of definitive evidence, the appropiate treatment of SB is still a
matter of debate.
The objective of the present study was to compare the treatment efficacy of occlusal
stabilization splint and Gabapentine on SB, using polysomnographically determined outcome
measures for the quantification of sleep bruxism.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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