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Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea

Sleep Apnea Clinical Trial

Official title:
Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep Apnea

Clinical Trial Summary

Obstructive sleep apnea (OSA) is a highly prevalent disorder with adverse neurocognitive and cardio-metabolic outcomes. Continuous positive airway pressure (CPAP) is the gold standard therapeutic option to treat airway obstructions during sleep and thus, prevent its adverse cardiovascular and neurocognitive outcomes. Previous clinical trials, however, have largely failed to show a consistent impact of CPAP on these health outcomes. One of the main limitations of these trials may be the inadequate characterization of OSA and its acute physiological consequences. By characterizing OSA based on the "apnea-hypopnea index (AHI)", there is a potential risk of negative results. In this trial, the investigators intend to tackle this issue, by better characterization of OSA-related physiological consequences during sleep using physiologically driven metrics to capture the burden of OSA-related hypoxemia ("hypoxic burden"), autonomic response ("heart rate burden"), and sleep fragmentation ("arousal burden").

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04575740
Study type Interventional
Source Brigham and Women's Hospital
Contact Nkiru G Ujomu
Phone 617-732-8976
Email nujomu@bwh.harvard.edu
Status Recruiting
Phase N/A
Start date September 10, 2020
Completion date June 30, 2024
View Details
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