Sleep Apnea Clinical Trial
Official title:
Obstructive Sleep Apneas in Elderly:Neuroimaging Changes and Neurocognitive Function Before and After Treatment
In the near future more than 20% of the European population will be over 65 years old and
the prevalence of obstructive sleep apnea (OSA) in this aged population is known to be
higher than 50%. OSA is a risk factor for cognitive dysfunction in middle-aged subjects, but
the relationship between cognitive impairment and sleep breathing disorders (SBD) in the
elderly has scarcely been observed.
The aim of this study is to investigate cognitive performance in elderly OSA patients, the
corresponding brain morphology changes and biological markers and their reversibility with
continuous positive airway pressure (CPAP) treatment.
Patients: We will include consecutive patients with a diagnosis of severe OSA (AHI> 30)
without significant comorbidities or excessive daytime sleepiness (Epworth ≤ 12). Patients
will be randomized to CPAP treatment or conservative treatment.
Methodology: We will assess at baseline and after 3 months of treatment:
1. Neuroimaging by MRI
2. Neurocognitive function with an extensive neuropsychological battery assessing
principally memory, attention and executive functions (Trail-making test A and B, Rey
Auditory Verbal Learning Test, Digit span, Digit symbol),
3. Biological markers of inflammation and endothelial dysfunction.
Patients included in the study will be monitored and followed for three months. They will be
examined at the time of inclusion, after two and six weeks and at the end (12 weeks) for
clinical monitoring and the evaluation of adaptation to treatment and compliance.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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