Sleep Apnea Clinical Trial
Official title:
Sleep Disordered Breathing in Patients With Chronic Pain and Long Term Opiate Therapy
Lay title: A study of breathing pauses during sleep in patients on long term opiates.
Sleep apnoea is a term which refers to frequent breathing pauses during sleep. Breathing can
stop at night due to the upper airway collapsing (Obstructive sleep apnoea)or reduced
signals from the brain driving breathing (central sleep apnoea). Clinical observation has
noticed that patients on opiates have an increase in sleep apnoea.
Hypothesis: This study looks at the relationship of opiates (when used for patients chronic
pain) and the occurrence of sleep apnoea. It is expected that there will be an increase in
sleep apnoea (particularly of the central variant) particularly in patients on long term
opiates.
The purpose for this study is to test the hypothesis that sleep disordered breathing is more
prevalent amongst a group of patients on high dose opiates for chronic pain.
Aims
1. To define the prevalence of sleep disordered breathing in a group of patients on oral
morphine for chronic pain.
2. To determine the prevalence of respiratory failure in this cohort of patients. Patients
on long term opiates (>6 months) from an outpatient pain clinic population on long
acting morphine formulations > 40 mg/day, Oxycontin 30 mg/day, and Methadone > 20
mg/day were prospectively recruited. Home polysomnograms were done on them. During
their clinical review they have spirometry, arterial blood gases, psychomotor vigilance
tests done on them.
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