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The Number and Function of Regular T Cell in Patients With Obstructive Sleep Apnea

Sleep Apnea Syndromes Clinical Trial

Official title:
Impact of Intermittent Hypoxia on the Number and Function of Regular T Cell in Patients With Obstructive Sleep Apnea

Clinical Trial Summary

To compare the number and function of regular T cell of patients with obstructive sleep apnea (OSA) versus that of age-, gender- and BMI (body mass index)-matched controls

Clinical Trial Description

Patients with obstructive sleep apnea (OSA) experience intermittent hypoxemia and arousal during sleep due to recurrent collapse of upper airway. Epidemiologic evidence showed they were at higher risk for autoimmune diseases. The regular T cell (Treg) has a crucial role in controlling autoimmunity. In this study, 40 OSA patients and 40 age-, gender- and BMI-matched controls will be recruited. Peripheral venous blood of the participants is drawn for numeration of CD4+CD25+FoxP3+ regular T cells by flow cytometry. As well, the CD4+CD25+ regular T cells are enriched by MACS and tested for their suppressive functions on proliferation assays. Th12+ CD4+ cells are also measured. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02342028
Study type Observational
Source Taipei Veterans General Hospital, Taiwan
Contact Kun-Ta Chou, MD
Phone +886-2-28712121
Email hbjoue@vghtpe.gov.tw
Status Recruiting
Phase N/A
Start date January 2015
Completion date December 2015
View Details
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