Lung Diseases Clinical Trial
To identify physiological and clinical measures of obstructive sleep-disordered breathing that are associated with increased morbidity in children.
BACKGROUND:
The study is in response to a Request for Applications (RFA) on Obstructive Sleep Apnea in
Children. NHLBI issued the RFA in December, 1997, with co-sponsorship from the National
Institute of Dental and Craniofacial Research and the National Institute of Child Health and
Human Development.
DESIGN NARRATIVE:
This cross-sectional study recruited a population-based sample of young children from among
the more than 8000 children in Massachusetts enrolled in the on-going Infant Care Practices
Study. Stratified sampling was used to assemble a cohort of 250 children with habitual
snoring (> 3 nights/week), 100 children with occasional snoring (<3 nights/week), and 100
non-snoring children. These children were studied within 3 months of their fourth birthday
using overnight laboratory polysomnography and a detailed neurobehavioral evaluation, in
order to test the hypothesis that, after adjusting for potential confounding variables, both
parent-reported snoring and polysomnographic measures were associated with standardized
measures of the following neurobehavioral domains: immediate attention, sustained attention,
working memory, and symptoms of hyperactivity. These data also provided an opportunity to
determine normal values for polysomnographic measures in 4-year-old children and to
determine the prevalence of snoring and polysomnographic abnormalities among 4-year-old
children.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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