Sleep Apnea, Obstructive Clinical Trial
Official title:
Microparticles as a Biomarker of Incident Cardiovascular Risk in Patients With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is independently associated with cardiovascular diseases,
including myocardial infarction and stroke. OSA may promote atherosclerosis risk factors such
as hypertension, diabetes and dyslipidemia and may have direct proatherogenic effects on the
vascular wall. A growing number of studies have recently focused on the role of
microparticles (MPs) in the atherogenic process. Case-control studies have shown that
platelet-, endothelial- and leukocyte-derived MP levels are increased in OSA and that
leukocyte-derived MP are released during the night in OSA. Furthermore, experimental evidence
shows that MPs from OSA patients induce endothelial dysfunction.
The objective of this prospective study is to evaluate the impact of increased levels of
leukocyte derived MPs on the cardiovascular outcomes in patients with prevalent
cardiovascular diseases investigated for OSA.
MPs are small plasma membrane vesicles that can be released by a variety of vascular or blood
cells and that contain membrane and cytosolic elements. Case-control studies have shown that
platelet-, endothelial- and leukocyte-derived MP levels are increased in OSA. Experimental
evidence shows that MPs from OSA patients induce endothelial dysfunction, inflammation, and
vascular hyperreactivity when injected to mice.
The impact of increased levels of MPs on the cardiovascular prognosis in OSA patient with
prevalent cardiovascular diseases in unknown.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03605329 -
Evaluation of the Severity of Cardiovascular Autonomic Neuropathy in Type 1 Diabetic Patients With OSAS
|
N/A | |
| Completed |
NCT04912635 -
Evaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project Neo
|
N/A | |
| Not yet recruiting |
NCT05939934 -
Impact of the Mandibular Advancement Device on Sleep Apnea During CPAP Withdrawal
|
N/A | |
| Enrolling by invitation |
NCT02290236 -
Monitored Saturation Post-ICU
|
N/A | |
| Terminated |
NCT02269774 -
Origin of Premature Atrial Beats Induced by Simulated Obstructive Sleep Apnea
|
N/A | |
| Completed |
NCT02088723 -
Testing the Elevation as Sleep Apnea Treatment
|
N/A | |
| Completed |
NCT02261857 -
3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea
|
Early Phase 1 | |
| Completed |
NCT01943708 -
Novel Auto-continuous Positive Airway Pressure (CPAP) Validation
|
Phase 3 | |
| Completed |
NCT01181570 -
Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea
|
Phase 4 | |
| Completed |
NCT00273754 -
The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA).
|
Phase 2 | |
| Recruiting |
NCT02166879 -
Undetected Sleep Apnea in the Postanesthesia Acute Care Unit (PACU)
|
||
| Recruiting |
NCT04963192 -
Integrated Management of Chronic Respiratory Diseases
|
N/A | |
| Completed |
NCT05056766 -
How Does the Clinical and Paraclinical Efficacy of an Oral Appliance Evolved According to Propulsion: Control With Each mm of Advancement
|
||
| Completed |
NCT04846400 -
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
|
N/A | |
| Recruiting |
NCT04314492 -
Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
|
N/A | |
| Completed |
NCT05175287 -
OSA (oRisk of Obstructive Sleep Apnea and Traffic Accidents Among Bus Drivers in Ecuador: is There a Significant Association
|
||
| Active, not recruiting |
NCT03431038 -
Cross-sectional Study of Prevalence Rate of Abdominal Aortic Aneurysm in OSAHS Patients From BTCH
|
N/A | |
| Enrolling by invitation |
NCT03075787 -
Cardiovascular Variability and Heart Rate Response Associated With Obstructive Sleep Apnea
|
N/A | |
| Completed |
NCT03300037 -
HYpopnea and Apnea Detection and Treatment Performance of a New cardiOreSpiratory Holter Monitor
|
N/A | |
| Recruiting |
NCT06097949 -
AcuPebble to Remotely Monitor Patients With OSA on CPAP Therapy
|