Sleep Apnea, Obstructive Clinical Trial
Oral appliances, which can maintain patients' jaw forwards during sleep, become more popular in treating obstructive sleep apnea (OSA). However, the exact mechanism of mandible forward on upper airway is not completely known. In this study we will use both static and dynamic MRI to study the 3D morphological changes and dynamic behavior of the upper respiratory tract at different mandible posits. Because in asian society non-obese OSA patients are not uncommonly seen, in this study we focus only on non-obese severe OSA patients.
The aim of this study is to analyze upper airway morphology changes and dynamic movement at
different sections affected by mandible position by using dynamic and static magnet
resonance imaging technique. The study also discusses the formation mechanism of obstructive
sleep apnea syndromes and function mechanism of the oral appliance, as well as the
evaluation of the clinical results of the oral appliance on non-obese male patients with
severe obstructive sleep apnea in Taiwan.
10 non-obese (BMI<25) severe OSA (AHI＞30) male patients between the age of 20 to 60 and 10
gender, BMI and age matched control (AHI＜5) were recruited for this study. Nine bite index
were made for the different mandible positions of the subjects.
Upper airway was imaged by using static and dynamic MRI of each subject wearing the bite
index while lying on the MRI scanning table. This study also measures the circumference and
takes the lateral cephalometric imaging of each subject. Oral appliances were made and
fitted for the experimental group subjects, who wore them for three months, after which they
transferred to the Sleep Center and underwent PSG examination to evaluate therapeutic
effects of the appliances.
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Observational Model: Case Control, Time Perspective: Prospective
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