Clinical Trials Logo
  1. Home
  2. Skin Neoplasms
  3. NCT00204789

Difluoromethylornithine (DFMO) Chemoprevention of Skin Cancer in Organ Transplant Recipients

Skin Neoplasms Clinical Trial

Official title:
Phase 2b Difluoromethylornithine (DFMO) Chemoprevention of Skin Cancer in Organ Transplant Recipients (OTR)

Clinical Trial Summary

This is a double blind, placebo controlled study of 52 patients who are at least one-year post-solid organ transplant. Subjects will receive either 12 months of DFMO or a placebo. The specific aims are to determine if DFMO at 500 mg daily will be well tolerated for 12 months and not affect organ transplant viability; will inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) in skin biopsies by approximately 50% for the 12 months of therapy; and will be able to decrease polyamine levels in skin biopsies for the 12 months of treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00204789
Study type Interventional
Source University of Wisconsin, Madison
Contact
Status Completed
Phase Phase 2
Start date July 2003
Completion date December 2007
View Details
See also
  Status Clinical Trial Phase
Completed NCT00027586 - Imatinib Mesylate in Treating Patients With Metastatic Melanoma Phase 2
Not yet recruiting NCT02230462 - Patient Satisfaction After Facial Reconstruction N/A
Terminated NCT02900248 - CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice
Completed NCT00224744 - Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage Phase 3
Completed NCT03132012 - Skin Health in Young Adults - Preventing Indoor Tanning and Promoting Sun Protection N/A
Terminated NCT00865878 - ALA-PDT Versus Vehicle PDT for Treatment of AK and Reduction of New NMSC in Solid Organ Transplant Recipients Phase 2
Not yet recruiting NCT05359419 - Comparison of Two Modes of Photodynamic Therapy for the Treatment of Actinic Keratosis on the Upper Extremities Phase 4
Active, not recruiting NCT00001813 - Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
Completed NCT02046811 - Reducing Skin Cancer Risk in Childhood Cancer Survivors N/A
Completed NCT02147080 - A Tailored Internet Intervention to Reduce Skin Cancer Risk Behaviors Among Young Adults N/A
Completed NCT00007631 - Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin Cancer Phase 3
Completed NCT00847912 - CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Phase 4
Recruiting NCT02836548 - HDAC Inhibitor Vorinostat in Resistant BRAF V600 Mutated Advanced Melanoma Phase 1/Phase 2
Completed NCT01482104 - New Versus Approved Methyl-aminolevulinate Photodynamic Therapy (MAL-PDT) Regime in Basal Cell Carcinoma (BCC) N/A
Enrolling by invitation NCT04630886 - Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery Early Phase 1
Completed NCT03012581 - Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types Phase 2
Withdrawn NCT02813902 - A Trial of Polypodium Leucotomos in Preventing Skin Cancer and Its Precursors Phase 1
Not yet recruiting NCT02408835 - Negative Pressure Wound Therapy in Groin Dissection N/A
Completed NCT02310503 - Spanish Registry of Mohs Surgery
Active, not recruiting NCT04267861 - M7824 Related Adverse Effects in Adults With Cancer