Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink

Skin Condition Clinical Trial

Official title:

Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05376657
• Other study ID #: 22-010-B
• Status: Completed
• Phase: N/A
• Start date: April 1, 2022
• Est. completion date: September 3, 2022

Study information

• Verified date: September 2022
• Source: TCI Co., Ltd.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To assess cherry collagen drink on skin condition improvement

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: September 3, 2022
• Est. primary completion date: July 20, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Healthy adults aged above 20 years old

Exclusion Criteria:

• Subject who is not willing to participate in this study.

• Patients with diseases of the skin, liver, kidney.

• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.

• Female who is pregnant or nursing or planning to become pregnant during the course of the study.

• Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.

• Constant drug use

• Students who are currently taking courses taught by the principal investigator of this trial.

• Body weight < 50 kg.

Related Conditions & MeSH terms

• Skin Condition
• Skin Diseases

Intervention

Dietary Supplement:
• Cherry collagen drink
consume 1 sachet per day
• Placebo drink
consume 1 sachet per day

Locations

Country	Name	City	State
Taiwan	Chia Nan University of Pharmacy & Science	Tainan City

Sponsors (1)

Lead Sponsor	Collaborator
TCI Co., Ltd.

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	The change of liver function biomarkers (AST, ALT) of blood	Venous blood was sampled to measure liver function biomarkers	Change from Baseline liver function biomarkers at 8 weeks
Other	The change of renal function biomarkers (creatinine, BUN) of blood	Venous blood was sampled to measure renal function biomarkers	Change from Baseline renal function biomarkers at 8 weeks
Other	The change of self-assessment skin condition	A self-assessment questionnaire was collected to evaluate skin condition	Change from Baseline skin condition at 8 weeks
Primary	The change of skin wrinkles	VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units	Change from Baseline skin wrinkles at 8 weeks
Primary	The change of skin texture	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units	Change from Baseline skin texture at 8 weeks
Primary	The change of skin collagen density	DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units	Change from Baseline skin collagen density at 8 weeks
Primary	The change of skin elasticity	Soft Plus was utilized to measure skin elasticity. Units: arbitrary units	Change from Baseline skin elasticity at 8 weeks
Secondary	The change of skin melanin index	Soft Plus was utilized to measure skin melanin index. Units: arbitrary units	Change from Baseline skin melanin index at 8 weeks
Secondary	The change of skin L* value	Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100	Change from Baseline L* value at 8 weeks
Secondary	The change of skin moisture	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120	Change from Baseline skin moisture at 8 weeks
Secondary	The change of skin spots	VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units	Change from Baseline skin spots at 8 weeks
Secondary	The change of skin UV spots	VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units	Change from Baseline skin UV spots at 8 weeks
Secondary	The change of skin brown spots	VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units	Change from Baseline skin brown spots at 8 weeks
Secondary	The change of SOD-RBC of blood	Venous blood was sampled to measure SOD-RBC	Change from Baseline SOD-RBC at 8 weeks
Secondary	The change of t-GSH of blood	Venous blood was sampled to measure t-GSH	Change from Baseline t-GSH at 8 weeks
Secondary	The change of GST-RBC of blood	Venous blood was sampled to measure GST-RBC	Change from Baseline GST-RBC at 8 weeks
Secondary	The change of blood total antioxidant capacity (TAC)	Venous blood was sampled to measure concentrations of TAC	Change from Baseline TAC at 8 weeks
Secondary	The change of desmosine of blood	Venous blood was sampled to measure concentrations of desmosine	Change from Baseline desmosine at 8 weeks
Secondary	The change of TNF-alpha of blood	Venous blood was sampled to measure concentrations of TNF-alpha	Change from Baseline TNF-alpha at 8 weeks
Secondary	The change of transepidermal water loss (TEWL)	Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²	Change from Baseline TEWL at 8 weeks