Skin Condition Clinical Trial
Official title:
Efficacy Evaluation of Pitaya Ovule Extract on Skin
Verified date | September 2022 |
Source | TCI Co., Ltd. |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To assess the efficacy of Pitaya Ovule Extract on skin
Status | Completed |
Enrollment | 50 |
Est. completion date | January 16, 2023 |
Est. primary completion date | December 23, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 65 Years |
Eligibility | Inclusion Criteria: - 20 to 65-year-old males or females Exclusion Criteria: - Received medical cosmetic treatment (including cosmetic skin care, laser, fruit acid peeling, injection or plastic surgery, etc.) currently or within one month before the trial - Outdoor workers (exposed to the sun more than 5 hours a day) - People who are breastfeeding, pregnant or planning to become pregnant during the test (self-report) - People with heart, liver, kidney, endocrine and other major organic diseases (self-reported) - People who have undergone major surgery (according to medical history) - People who take drugs for a long time - People with mental illness - Students who are currently taking courses taught by the principal investigator of this trial |
Country | Name | City | State |
---|---|---|---|
Taiwan | China Medical University | Taichung |
Lead Sponsor | Collaborator |
---|---|
TCI Co., Ltd. |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The change of L* (lightness) values | Spectrophotometer SCM-108 was utilized to measure skin L* value. Units: arbitrary units | Change from Baseline L* value at 8 weeks | |
Primary | The change of skin elasticity | Cutometer® Dual MPA580 was utilized to measure skin elasticity. Units: arbitrary units | Change from Baseline skin elasticity at 8 weeks | |
Primary | The change of skin collagen density | DermaLab® Combo Ultrasound module was utilized to measure skin collagen density. Units: arbitrary units | Change from Baseline skin collagen density at 8 weeks | |
Primary | The change of skin wrinkles | IRV skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units | Change from Baseline skin wrinkles at 8 weeks | |
Primary | The change of skin texture | IRV skin analyzer was utilized to measure skin texture. Units: arbitrary units | Change from Baseline skin texture at 8 weeks | |
Primary | The change of skin pores | IRV skin analyzer was utilized to measure skin pores. Units: arbitrary units | Change from Baseline skin pores at 8 weeks | |
Primary | The change of skin tone | IRV skin analyzer was utilized to measure skin tone. Units: arbitrary units | Change from Baseline skin tone at 8 weeks | |
Primary | The change of Advanced glycation end products of blood | Venous blood was sampled to measure AGEs | Change from Baseline AGEs at 8 weeks | |
Primary | The change of RAGE (receptor for advanced glycation end products) of blood | Venous blood was sampled to measure RAGE | Change from Baseline RAGE at 8 weeks | |
Primary | The change of Matrix metalloproteinases (MMP-2, MMP-9) of blood | Venous blood was sampled to measure MMPs | Change from Baseline MMPs at 8 weeks | |
Secondary | The change of liver function biomarkers (AST, ALT) of blood | Venous blood was sampled to measure liver function biomarkers | Change from Baseline liver function biomarkers at 8 weeks | |
Secondary | The change of renal function biomarkers (creatinine, BUN) of blood | Venous blood was sampled to measure renal function biomarkers | Change from Baseline renal function biomarkers at 8 weeks | |
Secondary | The change of fasting blood glucose level | Venous blood was sampled to measure fasting blood glucose level | Change from Baseline fasting blood glucose level at 8 weeks | |
Secondary | Change from Baseline insulin level at 8 weeks | Venous blood was sampled to measure insulin level | Change from Baseline insulin level at 8 weeks | |
Secondary | The change of blood lipid profile | Venous blood was sampled to measure blood lipid profile (total cholesterol, HDL-C, LDL-C, triglyceride) | Change from Baseline blood lipid profile at 8 weeks |
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