An Immunonutritional Approach to the Prevention of Skin Cancer

Status Completed

Clinical Trial Summary

Skin cancer incidence continues to rise and ultraviolet radiation (UVR) in sunlight is the principal cause. Solar UVR can promote cancer development through its ability to suppress the immune system. The purpose of this study is to determine whether dietary supplementation with omega-3 polyunsaturated fatty acids can protect human skin from UVR-induced immunosuppression.

Clinical Trial Description

Skin cancer is one of the most common human cancers with a rising incidence and considerable negative impact on human health. Exposure to ultraviolet radiation (UVR) in sunlight is the major aetiological factor in skin cancer initiation and progression. Human case-control studies have reported an inverse relationship between dietary fish or omega-3 polyunsaturated fatty acid (PUFA) intake and occurrence of non-melanoma skin cancer. Omega-3 PUFA have the potential to reduce the risk of photocarcinogenesis primarily by their ability to reduce production of prostaglandin E2 and consequently photoimmunosuppression. To date, no studies have assessed the impact of omega-3 PUFA on skin photoimmunosuppression in humans.

OBJECTIVE: To examine the potential of dietary omega-3 PUFA to protect against UVR-induced cutaneous immunosuppression in humans.

STUDY DESIGN: A double-blind randomised controlled nutritional study in 64 healthy human volunteers with nickel sensitivity. Volunteers will receive 3 months dietary supplementation with either omega-3 PUFA (n=32) or gelatine (n=32) both provided in identical gelatine capsules.

The aim is to quantify the influence of omega-3 PUFA on:

1. UVR-induced suppression of clinical contact hypersensitivity (CHS) responses

2. UVR-induced modulation of epidermal Langerhans cell trafficking

3. UVR-induced modulation of levels of immunoregulatory mediators ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01032343
Study type	Interventional
Source	University of Manchester
Contact
Status	Completed
Phase	N/A
Start date	July 2008
Completion date	November 2010

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT02721459` - XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma	Phase 1
Completed	`NCT03740815` - Feasibility of Serratus Plane Block Associated With Sedation in Axillary Dissection	N/A
Recruiting	`NCT05779423` - Cryoablation+Ipilimumab+Nivolumab in Melanoma	Phase 2
Terminated	`NCT01468818` - Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma	Phase 2
Completed	`NCT01820234` - Evaluation of Store-and-Forward Teledermatology Versus a Face-to-Face Assessment During a Skin Cancer Screening Event	N/A
Completed	`NCT00535769` - Evaluation of Adherence to Topical Agents: Applying Communication Technology to Improve Sunscreen Use	Phase 0
Completed	`NCT00526032` - Melanoma Detection by Oblique-Incidence Optical Spectroscopy	N/A
Completed	`NCT00588341` - Phase II Trial of Neoadjuvant Temozolomide in Melanoma Patients With Palpable Stage III or IV Disease Undergoing Complete Surgical Resection	Phase 2
Active, not recruiting	`NCT01447199` - The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
Enrolling by invitation	`NCT04758988` - AI Augmented Training for Skin Specialists	N/A
Not yet recruiting	`NCT04534868` - Patient Acceptance And Satisfaction of Teledermoscopy In General Practice In a Belgian Rural Area	N/A
Recruiting	`NCT04138342` - Topical Fluorescent Nanoparticles Conjugated Somatostatin Analog for Suppression and Bioimaging Breast Cancer	Phase 1
Completed	`NCT03673917` - Cosmetology Students and Skin Cancer	N/A
Recruiting	`NCT04341064` - Sun-safe Habits Intervention and Education	Phase 3
Completed	`NCT04206995` - Cancer Sensing: Evaluation of Odour Sampling Techniques
Recruiting	`NCT05574101` - A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer	Phase 2
Not yet recruiting	`NCT05860881` - Topical Sirolimus in Chemoprevention of Facial Squamous Cell Carcinomas in Solid Organ Transplant Recipients (SiroSkin)	Phase 3
Completed	`NCT05146622` - Virtual Sun Safe Workplaces Ph I
Recruiting	`NCT05068310` - Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors
Recruiting	`NCT03889899` - Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia.	N/A