Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

Skin Cancer Clinical Trial

Official title:

Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00849914
• Other study ID #: 005
• Status: Completed
• Phase: N/A
• First received: February 20, 2009
• Last updated: October 15, 2012
• Start date: July 2008
• Est. completion date: February 2009

Study information

• Verified date: October 2012
• Source: Ruhr University of Bochum
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Observational

Clinical Trial Summary

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: February 2009
• Est. primary completion date: February 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin

Exclusion Criteria:

• Patients under 18 years of age

• Patients with other forms of cancer in previous medical history

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Skin Cancer
• Skin Neoplasms

Locations

Country	Name	City	State
Germany	Department of Dermatology and Allergology, Ruhr-University Bochum	Bochum

Sponsors (1)

Lead Sponsor	Collaborator
Ruhr University of Bochum

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, Bechara FG. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010 Jul;28(6):649-53. doi: 10.3109/07357901003630918. — View Citation