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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03730649
Other study ID # IRB00184806
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date October 9, 2019
Est. completion date April 2025

Study information

Verified date June 2024
Source Johns Hopkins University
Contact Ruizhi Wang
Phone 410-502-7546
Email rwang53@jhmi.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The study is to compare the expression of both keratin 16 and 17 before and after application of sulforaphane on both photoprotected and photoexposed area, and to determine whether these findings alter skin aging as well as skin response to ultraviolet (UV) and visible light exposure.


Description:

The study is to compare the expression of both keratin 16 and 17 before and after application of sulforaphane on both photoprotected and photoexposed area, and to determine whether these findings alter skin aging as well as skin response to ultraviolet (UV) and visible light exposure. Each study participant will have up to eight study visits. Topical sulforaphane will be applied for up to 6 months. Photography, clinical assessment, UV light irradiation, Visible light treatment, Skin biopsies, non invasive elasticity measurements such as cutometer and ballistometer, and others will be involved in this study.


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Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Sulforaphane (broccoli sprout extract)
Participants will topically apply Sulforaphane for a period of time
Radiation:
UV or visible light
Participants will have 2 test areas irradiated with up to 5 UV or visible light treatments

Locations

Country Name City State
United States Cutaneous Translational Research Program, Department of Dermatology, Johns Hopkins University School of Medicine Baltimore Maryland

Sponsors (1)

Lead Sponsor Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

References & Publications (7)

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Outcome

Type Measure Description Time frame Safety issue
Primary keratin 16 presence as determined by immunofluorescence assay The investigators will detect the presence of keratin 16 in the basal layer of the epidermis in both photoprotected and photodamaged skin treated with sulforaphane (SF), by immunofluorescence assay, to determine whether SF can improve skin fragility and other features seen in these conditions Up to 6 months
Primary keratin 17 presence as determined by immunofluorescence assay The investigators will detect the presence of keratin 17 in the basal layer of the epidermis in both photoprotected and photodamaged skin treated with SF, by immunofluorescence assay, to determine whether SF can improve skin fragility and other features seen in these conditions Up to 6 months
Primary keratin 16 fold change as determined by Reverse Transcription Polymerase Chain Reaction (RT-PCR) The investigators will detect the fold change of keratin 16 in the basal layer of the epidermis in both photoprotected and photodamaged skin treated with SF, by RT-PCR, to determine whether SF can improve skin fragility and other features seen in these conditions Up to 6 months
Primary keratin 17 fold change as determined by RT-PCR The investigators will detect the fold change of keratin 17 in the basal layer of the epidermis in both photoprotected and photodamaged skin treated with sulforaphane (SF), by RT-PCR, to determine whether SF can improve skin fragility and other features seen in these conditions Up to 6 months
Secondary keratin expression changes as determined by RT-PCR The investigators will test the fold change of keratin expression in human skin after acute UV and visible light light exposure, separately and in combination with application of topical sulforaphane by RT-PCR. Up to 6 months
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