Clinical Trials Logo

Clinical Trial Summary

The most visible signs of aging are on the skin. As skin gets older it shows a decrease in epidermal thickness, with a flattening of the dermal-epidermal junction. At the same time, loss of elasticity and wrinkle formation begin. The objective of this randomized, triple-blind, placebo-controlled study is to evaluate the efficacy of Vinh Wellness Collagen on skin elasticity, wrinkles, and hydration over 12 weeks.


Clinical Trial Description

Skin appearance is known to be influenced by endogenous and environmental factors, including nutrition, hormones, as well as exposure to chemicals, smoking, or ultraviolet radiation. The ability of nutritional supplements to enhance skin characteristics has received increasing attention as the population continues aging. A recent study assessed the correlation between nutrient consumption and skin-aging appearance, including skin wrinkles, dryness, and atrophy, and determined that higher intake of linoleic acid and vitamin C, as well as lower intake of fats and carbohydrates are linked with improved skin appearance. Moreover, clinical trials examining the effects of nutritional supplementation with proteins, vitamins, fatty acids, and trace minerals, have suggested that dietary compounds can modulate skin health and function.

As skin gets older it shows a decrease in epidermal thickness, with a flattening of the dermal-epidermal junction. The dermis is the skin layer directly below the epidermis and has decreases in thickness by about 1% per year throughout the adult lifespan. Structural components of the dermis include collagen, elastic fibers, and extrafibrillar matrix. The cosmetic industry has focused its research on supporting these connective tissue components, as they have been established to repair skin damage (i.e. wounds) and enhance the strength and radiance of the skin.

Collagen is the most abundant protein in mammals and is currently being utilized by a diverse number of industries including nutrition, cosmetic, and biomedical fields. Gelatin, which is used extensively in the food sector, is a hydrolyzed analog of collagen and is an excellent source of protein. A subsequent enzymatic degradation of gelatin results in the generation of collagen hydrolysate (CH), which contains peptides of an average molecular weight of 3-6 kDa. Human bioavailability studies have demonstrated that hydrolyzed collagen peptides are present in the blood within 2 h following oral ingestion of gelatin derived from chicken or fish and are present up to 24 h later.

A double-blind, placebo-controlled trial on 69 women treated with a daily CH treatment or placebo for 8 weeks reported that skin elasticity was significantly improved. Skin moisture and skin evaporation were also enhanced but did not reach statistical significance relative to the placebo group. In addition, other studies have examined the effect of daily ingestion of CH (10 g) or placebo on skin hydration in healthy Japanese women over 2 months and found that there was a gradual improvement in skin water absorption capacity. The objective of this randomized, triple-blind, placebo-controlled study is to evaluate the efficacy of Vinh Wellness Collagen, a CH derived from pangasius skin, on skin elasticity, wrinkles, and hydration over 12 weeks of use. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04449159
Study type Interventional
Source Vinh Hoan Corporation
Contact
Status Completed
Phase N/A
Start date November 25, 2016
Completion date May 16, 2018

See also
  Status Clinical Trial Phase
Completed NCT05597254 - Facial Skin Clinical and Microbial Profiling From Oral Probiotic Supplementation N/A
Active, not recruiting NCT06140628 - A 28-day Clinical Study on Facial Skin Rejuvenation N/A
Completed NCT04154436 - Effectiveness, Safety, and Cost Efficacy of Water (H2O) as a Substitute for Sodium Bicarbonate (NaHCO3) Plus Solution in Neutralization of Chemical Peeling Using 35% Glycolic Acid Solution N/A
Withdrawn NCT02787356 - Standard TDS Irritation Study: Trained Skin Grader vs. Digital Imaging N/A
Enrolling by invitation NCT06188338 - A 56-day Clinical Study on Facial Skin Rejuvenation N/A
Completed NCT01139047 - Split-face Tolerability Comparison Between MetroGel® 1% vs Finacea® 15% in Subjects With Healthy Skin Phase 4
Completed NCT01139008 - Split-Face Tolerability Comparison Between MetroGel® 1% Versus Finacea® 15% in Subjects With Healthy Skin Phase 4
Completed NCT05094687 - Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
Recruiting NCT05235997 - Placebo Controlled Efficacy Evaluation of the Hydrolyzed Collagen Peptide In Adult Females N/A
Completed NCT01046396 - Tolerability Comparison of Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin Phase 1
Completed NCT01046565 - Tolerability Comparison Between Differin® Cream 0.1% Versus Differin® Lotion 0.1% in Subjects With Healthy Skin Phase 1
Completed NCT04701463 - A Specialized Amino Acid Mixture on Body Composition and Skin State in Overweight and Obese Class I Postmenopausal Women N/A
Completed NCT02422836 - Tolerability and Efficacy of Anti-Aging Treatment Regimen in Subjects With Photodamage N/A
Completed NCT04002856 - Aesthetic Performance of "Profhilo®" Injective Intradermal Treatment for the Neck N/A
Completed NCT03873896 - The Skin Wrinkle Test: a Simple Clinical Test of Regional Block Success N/A
Completed NCT03505684 - Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women N/A
Active, not recruiting NCT06152718 - New Regenerative Approach for Dermal Renovation (Karisma)
Recruiting NCT04344119 - Assessment of Chilbains Occuring During Covid-19 Infection
Recruiting NCT06291415 - The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP) Phase 1
Completed NCT05872178 - Omegia Softgel Clinical Research Program N/A