Skin Abnormalities Clinical Trial
Official title:
A Randomized, Triple-blind, Placebo-controlled, Parallel Study to Evaluate the Efficacy of Vinh Wellness Collagen on Skin Elasticity, Wrinkles, and Moisturizing Effect
The most visible signs of aging are on the skin. As skin gets older it shows a decrease in epidermal thickness, with a flattening of the dermal-epidermal junction. At the same time, loss of elasticity and wrinkle formation begin. The objective of this randomized, triple-blind, placebo-controlled study is to evaluate the efficacy of Vinh Wellness Collagen on skin elasticity, wrinkles, and hydration over 12 weeks.
Skin appearance is known to be influenced by endogenous and environmental factors, including
nutrition, hormones, as well as exposure to chemicals, smoking, or ultraviolet radiation. The
ability of nutritional supplements to enhance skin characteristics has received increasing
attention as the population continues aging. A recent study assessed the correlation between
nutrient consumption and skin-aging appearance, including skin wrinkles, dryness, and
atrophy, and determined that higher intake of linoleic acid and vitamin C, as well as lower
intake of fats and carbohydrates are linked with improved skin appearance. Moreover, clinical
trials examining the effects of nutritional supplementation with proteins, vitamins, fatty
acids, and trace minerals, have suggested that dietary compounds can modulate skin health and
function.
As skin gets older it shows a decrease in epidermal thickness, with a flattening of the
dermal-epidermal junction. The dermis is the skin layer directly below the epidermis and has
decreases in thickness by about 1% per year throughout the adult lifespan. Structural
components of the dermis include collagen, elastic fibers, and extrafibrillar matrix. The
cosmetic industry has focused its research on supporting these connective tissue components,
as they have been established to repair skin damage (i.e. wounds) and enhance the strength
and radiance of the skin.
Collagen is the most abundant protein in mammals and is currently being utilized by a diverse
number of industries including nutrition, cosmetic, and biomedical fields. Gelatin, which is
used extensively in the food sector, is a hydrolyzed analog of collagen and is an excellent
source of protein. A subsequent enzymatic degradation of gelatin results in the generation of
collagen hydrolysate (CH), which contains peptides of an average molecular weight of 3-6 kDa.
Human bioavailability studies have demonstrated that hydrolyzed collagen peptides are present
in the blood within 2 h following oral ingestion of gelatin derived from chicken or fish and
are present up to 24 h later.
A double-blind, placebo-controlled trial on 69 women treated with a daily CH treatment or
placebo for 8 weeks reported that skin elasticity was significantly improved. Skin moisture
and skin evaporation were also enhanced but did not reach statistical significance relative
to the placebo group. In addition, other studies have examined the effect of daily ingestion
of CH (10 g) or placebo on skin hydration in healthy Japanese women over 2 months and found
that there was a gradual improvement in skin water absorption capacity. The objective of this
randomized, triple-blind, placebo-controlled study is to evaluate the efficacy of Vinh
Wellness Collagen, a CH derived from pangasius skin, on skin elasticity, wrinkles, and
hydration over 12 weeks of use.
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