Skeletal Muscle Physiology Clinical Trial
Official title:
Proteome Remodelling and Dynamics in Human Skeletal Muscle: Effect of Training
NCT number | NCT04136457 |
Other study ID # | MiDy |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | October 30, 2019 |
Est. completion date | November 28, 2023 |
Verified date | December 2023 |
Source | University of Copenhagen |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of the project is to investigate the proteome signature dynamics and remodelling in human skeletal muscle induced by exercise training
Status | Completed |
Enrollment | 72 |
Est. completion date | November 28, 2023 |
Est. primary completion date | November 28, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Healthy men and women - VO2max > 55 mL/min/kgLM for men and > 50 for women (only applicable for endurance and sprint training interventions) - BMI < 26 Exclusion Criteria: - Chronic disease deemed by the medical doctor to pose a risk or to affect study outcomes - smoking - Use of prescription medicine deemed by the medical to affect study outcomes - Pregnancy |
Country | Name | City | State |
---|---|---|---|
Denmark | August Krogh Building | Copenhagen |
Lead Sponsor | Collaborator |
---|---|
Morten Hostrup, PhD |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Skeletal muscle mitochondrial supercomplexes | Pathway enrichment analysis of mitochondrial supercomplexes | Change from baseline at week 6 following endurance and sprint training | |
Primary | Skeletal muscle proteome signature | Pathway enrichment analysis of the muscle proteome | Change from baseline at week 6 or 8 depending on the intervention | |
Primary | Anabolic signaling | Western blotting of proteins related to anabolic signaling | Change in anabolic signaling from rest to 1 hour following resistance exercise both at baseline and following 8 weeks of resistance training | |
Secondary | Skeletal muscle mitochondrial respiration | High resolution respirometry | Change from baseline at week 6 following endurance and sprint training | |
Secondary | Maximal oxygen consumption | VO2max during incremental exercise | Change from baseline at week 6 following endurance and sprint training | |
Secondary | Body composition | Lean and fat mass during dual X-ray absorptiometry | Change from baseline at week 6 or 8 depending on the intervention | |
Secondary | Myonuclei | Immunohistochemistry to determine number of myonuclei | Change from baseline at week 8 following resistance training | |
Secondary | Satellite cells | Immunohistochemistry to determine number of satellite cells | Change from baseline at week 8 following resistance training | |
Secondary | Fiber size | Immunohistochemistry to determine fiber size | Change from baseline at week 8 following resistance training |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
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