Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis

Status Recruiting

Clinical Trial Summary

The aim of this study is to find out if endoscopic sinus surgery improves the quality of life in patients suffering from recurrent acute rhinosinusitis. Our main outcome is the difference between the average change in disease-specific SNOT-22 quality of life questionnaire scores (from baseline to 5-6 months follow-up) between the intervention and the control groups.

Clinical Trial Description

This is a randomized controlled trial. Patients suffering from recurrent acute sinusitis episodes will be randomly allocated to two groups: intervention group, where they will receive endoscopic sinus surgery in addition to medical treatment and control group, where they will receive mere medical treatment. Both groups will be followed-up for 5 to 6 months. At baseline and after 5 to 6 months, patients will answer the life quality questionnaires SNOT-22 and RAND 36-item Health Survey. The numbers of sinusitis episodes, medical appointments for respiratory symptoms, use of medications, numbers of days lost from work or studies and numbers of days with various respiratory and adverse symptoms will be recorded with patient diaries. The potential serious adverse events (e.g. cerebrospinal fluid leak, orbital complications) related to surgery will be collected from the medical records. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04241016
Study type	Interventional
Source	Oulu University Hospital
Contact	Heidi M Kaski, MD
Phone	+385442730022
Email	heidi.kaski@student.oulu.fi
Status	Recruiting
Phase	N/A
Start date	May 1, 2020
Completion date	May 30, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03584178` - The Long-Term Safety of Budesonide for Patients With Chronic Rhinosinusitis	N/A
Completed	`NCT06016335` - MRI-based Synthetic CT Images of the Head and Neck	N/A
Active, not recruiting	`NCT02278484` - Sinus Balloon Dilation in Pediatric Patients	N/A
Withdrawn	`NCT02071667` - Association of Periostin Levels and Chronic Sinusitis	N/A
Completed	`NCT01420471` - Medicated Punctured-Glove-Finger Spacer Study	Phase 4
Completed	`NCT01118312` - Study of Asthma and Nasal Steroids	Phase 4
Completed	`NCT00645762` - Balloon REmodeling Antrostomy THErapy Study	Phase 2
Completed	`NCT01685229` - Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
Active, not recruiting	`NCT03943121` - The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	N/A
Withdrawn	`NCT02900794` - Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery	N/A
Terminated	`NCT02630472` - Topical Irrigation Therapy for CRS	Phase 1/Phase 2
Completed	`NCT01442740` - 15-Degree Tilt, Head Up, Feet Down Body Position for Sinus Surgery Patients	N/A
Completed	`NCT01001039` - Validation of the Facial and Cephalic Pain Inventory	N/A
Completed	`NCT01033799` - Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers	N/A
Completed	`NCT00242437` - Hemostatic Matrix in Endoscopic Sinus Surgery	Phase 4
Completed	`NCT00335309` - Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis	N/A
Completed	`NCT00236522` - A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults.	Phase 3
Not yet recruiting	`NCT06089278` - A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps.	Phase 2
Completed	`NCT01717274` - Hot Saline Irrigation Study	N/A
Completed	`NCT01166945` - Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children	N/A