Sinusitis Clinical Trial
Official title:
Olfactory Dysfunction of Rhinosinusitis - cAMP/Calcium Signaling Study
The study examines the biochemistry underlying human olfaction in both normal and diseased
states.
The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with
chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory
function with cAMP levels from biopsied olfactory tissue. 3. to determine odorant and
pheromone-mediated activation of cultured human olfactory sensory neurons using calcium
imaging and 4. to determine odorant and pheromone-mediated activation of cultured human
olfactory sensory neurons using "smell-chip" technology.
Subject will be recruited from those scheduled to have endoscopic sinus surgery and similar
procedures. This study uses the tissue that would normally be discarded during the surgical
process. The tissue is cultured and frozen for purposes of the following testing:
odor detection and signal transduction, cyclic adenosine monophosphate and odor detection,
the role of cAMP in olfactory dysfunction, and pheromone detection.
Only tissue that would normally be discarded during the course of the surgery will be used.
The study does not interfere with or change any clinical care.
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Observational Model: Cohort, Time Perspective: Prospective
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