Sinusitis Clinical Trial
Official title:
A Multicenter, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Levofloxacin 750 mg Once Daily for 5 Days Versus Levofloxacin 500 mg Once Daily for 10 Days in the Treatment of Acute Bacterial Sinusitis in Adults.
The purpose of this study is to evaluate the effectiveness and safety of two antibiotic regimens in the treatment of acute bacterial sinusitis (sinus infection) in non-hospitalized adult patients. A 5-day course of 750 milligrams of levofloxacin given by mouth once daily will be compared to a 10-day course of 500 milligrams of levofloxacin given by mouth once daily.
When treating sinus infections (sinusitis) caused by bacteria, the traditional duration of
therapy is between 10 and 14 days. In this randomized, double-blind study, 5 days of 750
milligrams of levofloxacin given once daily will be compared to 10 days of 500 milligrams of
levofloxacin in the treatment of non-hospitalized adult patients who have acute bacterial
sinusitis. To prevent the study doctor, study staff and patients from knowing which study
drug they are taking, all study drug will manufactured to look the same and patients on the
5-day regimen will be given placebo for the last 5 days of their participation in the study.
Patients will have a sinus specimen collected at the first visit. Safety evaluations will be
conducted. The objective of the study is to demonstrate that, in the treatment of acute
bacterial sinus infections, a 5-day course of 750 milligrams of levofloxacin given once
daily is at least as effective as a 10-day course of 500 milligrams of levofloxacin given
once daily and is well tolerated.
Patients will take by mouth 750 milligrams levofloxacin capsules once daily for 5 days
followed by placebo capsules once daily for 5 days, or 500 milligrams levofloxacin capsules
once daily for 10 days.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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