Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children

Status Completed

Clinical Trial Summary

Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause. The investigators have preliminary data to support the notion that pediatric chronic sinusitis is a distinct disease, different from acute sinusitis and adult chronic sinusitis. We are proposing to perform pathogenesis studies in children with chronic sinusitis. Specifically, we wish to elucidate the microbiologic features and immunologic factors involved in the formation of this disease. The study plan calls for microbiologic (bacterial, viral, and fungal) and immunologic (inflammatory mediators and leukocyte populations) data to be evaluated through a maxillary sinus washing and mucosal biopsies. Four populations will be studied and they are: 10 children with chronic sinusitis, 5 children with acute sinusitis (positive control), 5 children without sinusitis (negative control) and 5 adults with chronic sinusitis (positive secondary control).

Clinical Trial Description

n/a

Study Design

Primary Purpose: Diagnostic

Related Conditions & MeSH terms

Sinusitis

Clinical Trial Details

NCT number	NCT00004638
Study type	Interventional
Source	National Center for Research Resources (NCRR)
Contact
Status	Completed
Phase	N/A

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