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Sinus Infection clinical trials

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NCT ID: NCT06076304 Active, not recruiting - Acute Sinusitis Clinical Trials

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

NOSES
Start date: November 21, 2023
Phase: Phase 4
Study type: Interventional

Sinus infections are sometimes treated with antibiotics or nasal sprays, while some patients get better on their own. Some patients may wait a few days or use common over-the-counter remedies to see if their symptoms improve without further treatment. The overall goal of this clinical trial to see which patients with sinus infections are more likely to respond to different treatments, and which improve with supportive care alone.

NCT ID: NCT05954273 Enrolling by invitation - Clinical trials for Sinus Floor Augmentation

Maxillary Sinus Membrane Perforation Incidence During Osseodensification

Start date: April 3, 2023
Phase:
Study type: Observational

Measure the incidence of the maxillary sinus membrane perforation during the Osseodensification crestal sinus grafting procedure.

NCT ID: NCT05454072 Recruiting - Sinusitis, Chronic Clinical Trials

Microbiota Transfer for Chronic Rhinosinusitis

SNMT
Start date: June 15, 2022
Phase: N/A
Study type: Interventional

Chronic sinusitis (CRS) is a common inflammatory condition of the sinuses that affects up to 2.5% of the Canadian population, and is thought to be caused by bacterial infection, resistant biofilms, chronic inflammation and possibly an unhealthy population of sinus microbes (or microbiota). Symptoms include nasal obstruction and discharge, facial pain, loss of smell and sleep disturbance, which all strongly impact quality of life. CRS treatment involves nasal or oral steroids, repeated rounds of antibiotic, and sinus surgery. Despite maximal treatment, some recalcitrant patients suffer with CRS for years. The lack of new, effective therapies to treat CRS leads the investigators to test whether a SinoNasal Microbiota Transfer (SNMT) could trigger CRS recovery. SNMT is defined as the endoscopic transfer of a healthy sinus microbiota from a fully screened donor's sinus to a CRS patient's sinus(es). Similar to a fecal transplant used to treat Clostridioides difficile diarrhea, the sinonasal microbiota transfer may eliminate sinus pathogens and restore the sinus microbiota to a healthy state. SNMT will be combined with a one-time, high volume, high pressure "sinus power wash" pre-treatment to temporarily clear the way for the donor microbiota to establish itself. The investigators will conduct a proof-of-principle, randomized, double-blind, placebo-controlled trial of 80 subjects to test whether a sinus power wash plus SNMT improves clinical outcomes in CRS patients.

NCT ID: NCT05102539 Enrolling by invitation - Sinus Infection Clinical Trials

Causes of Non-invasive Fungal Sinusitis as Presented in Sohag University Hospital

Start date: October 2021
Phase:
Study type: Observational

in this study, the investigators will collect data from patients with non-invasive fungal sinusitis to know what causes it

NCT ID: NCT03729258 Recruiting - Sinusitis Clinical Trials

Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.

Start date: May 15, 2019
Phase: Phase 3
Study type: Interventional

The aim of this study is to compare the efficacy and safety of cefpodoxime 200 mg immediate (b.i.d) and cefpodoxime 400 mg modified release (q.d) tablet formulations in the treatment of acute bacterial rhinosinusitis.